8BWU
Crystal structure of SARS-CoV-2 nsp14 methyltransferase domain in complex with the SS148 inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Transcription factor ETV6,Proofreading exoribonuclease nsp14 | polymer | 308 | 35526.4 | 1 | UniProt (P41212) UniProt (P0DTD1) Pfam (PF02198) Pfam (PF06471) In PDB | Severe acute respiratory syndrome coronavirus 2 | ETS translocation variant 6,ETS-related protein Tel1,Tel,ExoN,Guanine-N7 methyltransferase,Non-structural protein 14,nsp14 |
| 2 | A | (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(4-azanyl-5-cyano-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid | non-polymer | 408.4 | 1 | Chemie (6NR) | |||
| 3 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | water | water | 18.0 | 26 | Chemie (HOH) |
Sequence modifications
A: 220 - 296 (UniProt: P41212)
A: 300 - 527 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Glu 285 | Val 112 | conflict |
| Pro 297 | - | linker |
| Ala 298 | - | linker |
| Ala 299 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35526.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 473.8 | |
| All* | Total formula weight | 36000.3 |
