8BWQ

Cryo-EM structure of nanodisc-reconstituted wildtype human MRP4 (in complex with topotecan)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	ATP-binding cassette sub-family C member 4	polymer	1325	149693.9	1	UniProt (O15439) Pfam (PF00664) Pfam (PF00005)	Homo sapiens (human)	MRP/cMOAT-related ABC transporter,Multi-specific organic anion transporter B,MOAT-B,Multidrug resistance-associated protein 4
2	B (A)	(S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE	non-polymer		421.4	1	Chemie (TTC)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	149693.9
Non-Polymers*	Number of molecules	1
	Total formula weight	421.4
All*	Total formula weight	150115.4

*Water molecules are not included.