8BWN
Crystal structure of human Twisted gastrulation protein homolog 1 (TWSG1) in complex with human Growth Differentiation Factor 5 (GDF5) and calcium, long-wavelength X-ray dataset (4010 eV)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Growth/differentiation factor 5 | polymer | 121 | 13729.8 | 2 | UniProt (P43026) Pfam (PF00019) | Homo sapiens (human) | GDF-5,Bone morphogenetic protein 14,BMP-14,Cartilage-derived morphogenetic protein 1,CDMP-1,Lipopolysaccharide-associated protein 4,LAP-4,LPS-associated protein 4,Radotermin |
| 2 | C, D (C, D) | Twisted gastrulation protein homolog 1 | polymer | 69 | 7499.7 | 2 | UniProt (Q9GZX9) | Homo sapiens (human) | |
| 3 | E, F, G (A, B, D) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 4 | H, I, J, K (A, B, C, D) | water | water | 18.0 | 45 | Chemie (HOH) |
Sequence modifications
A, B: 382 - 501 (UniProt: P43026)
C, D: 26 - 83 (UniProt: Q9GZX9)
| PDB | External Database | Details |
|---|---|---|
| Met 381 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Glu 23 | - | expression tag |
| Thr 24 | - | expression tag |
| Gly 25 | - | expression tag |
| Gly 84 | - | expression tag |
| Thr 85 | - | expression tag |
| Leu 86 | - | expression tag |
| Glu 87 | - | expression tag |
| Val 88 | - | expression tag |
| Leu 89 | - | expression tag |
| Phe 90 | - | expression tag |
| Gln 91 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 42459.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 120.2 | |
| All* | Total formula weight | 42579.4 |
