8BWH
Small molecule stabilizer for 14-3-3/ChREBP (Cmd 42)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 14-3-3 protein sigma | polymer | 236 | 26542.9 | 1 | UniProt (P31947) Pfam (PF00244) | Homo sapiens (human) | Epithelial cell marker protein 1,Stratifin |
| 2 | B (B) | Carbohydrate-responsive element-binding protein | polymer | 18 | 2383.8 | 1 | UniProt (C9JDF5) UniProt (by SIFTS) (Q9NP71) | Homo sapiens | |
| 3 | C, D, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 4 | F (A) | [2-[2-[[2,2-bis(fluoranyl)-2-(2-fluorophenyl)ethyl]amino]-2-oxidanylidene-ethoxy]phenyl]phosphonic acid | non-polymer | 389.3 | 1 | Chemie (XSL) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 136 | Chemie (HOH) |
Sequence modifications
A: 1 - 231 (UniProt: P31947)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28926.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 462.2 | |
| All* | Total formula weight | 29388.8 |
