8BW3

PanDDA analysis -- Crystal Structure of PHIP in complex with Z198194396 synthetic derivative

Replaces:  5S9H

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	PH-interacting protein	polymer	149	17627.9	1	UniProt (Q8WWQ0) Pfam (PF00439) In PDB	Homo sapiens (human)	PHIP,DDB1- and CUL4-associated factor 14,IRS-1 PH domain-binding protein,WD repeat-containing protein 11
2	A	(2S)-N-(cyclopropylmethyl)-2-methyl-4-(1-methyl-1H-pyrrole-2-carbonyl)piperazine-1-carboxamide	non-polymer		304.4	1	Chemie (Y3V)
3		water	water		18.0	125	Chemie (HOH)

Sequence modifications

A: 1309 - 1440 (UniProt: Q8WWQ0)

PDB	External Database	Details
Met 1292	-	initiating methionine
His 1293	-	expression tag
His 1294	-	expression tag
His 1295	-	expression tag
His 1296	-	expression tag
His 1297	-	expression tag
His 1298	-	expression tag
Ser 1299	-	expression tag
Ser 1300	-	expression tag
Gly 1301	-	expression tag
Val 1302	-	expression tag
Asp 1303	-	expression tag
Leu 1304	-	expression tag
Gly 1305	-	expression tag
Thr 1306	-	expression tag
Glu 1307	-	expression tag
Asn 1308	-	expression tag
Tyr 1310	Arg 1310	expression tag
Phe 1311	Asn 1311	expression tag
Gln 1312	Arg 1312	expression tag
Ser 1313	Ala 1313	expression tag
Met 1314	Gln 1314	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	17627.9
Non-Polymers*	Number of molecules	1
	Total formula weight	304.4
All*	Total formula weight	17932.2

*Water molecules are not included.