8BU5
Structure of DDB1 bound to SR-4835-engaged CDK12-cyclin K
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G (A, D, G) | DNA damage-binding protein 1 | polymer | 840 | 93675.4 | 3 | UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) | Homo sapiens (human) | DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe |
| 2 | B, E, H (B, E, H) | Cyclin-dependent kinase 12 | polymer | 344 | 40143.3 | 3 | UniProt (Q9NYV4) Pfam (PF00069) | Homo sapiens (human) | Cdc2-related kinase,arginine/serine-rich,CrkRS,Cell division cycle 2-related protein kinase 7,CDC2-related protein kinase 7,Cell division protein kinase 12,hCDK12 |
| 3 | C, F, I (C, F, I) | Cyclin-K | polymer | 271 | 31700.5 | 3 | UniProt (O75909) Pfam (PF00134) Pfam (PF21797) | Homo sapiens (human) | |
| 4 | J, O, Q (A, G, H) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 5 | K, M, P (B, E, H) | ~{N}-[[5,6-bis(chloranyl)-1~{H}-benzimidazol-2-yl]methyl]-9-(1-methylpyrazol-4-yl)-2-morpholin-4-yl-purin-6-amine | non-polymer | 499.4 | 3 | Chemie (RMF) | |||
| 6 | L, N, R (C, F, I) | CITRIC ACID | non-polymer | 192.1 | 3 | Chemie (CIT) |
Sequence modifications
A, D, G: 1 - 699 (UniProt: Q16531)
A, D, G: 706 - 1140 (UniProt: Q16531)
B, E, H: 712 - 1051 (UniProt: Q9NYV4)
C, F, I: 1 - 267 (UniProt: O75909)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Arg 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 700 | - | linker |
| Asn 701 | - | linker |
| Gly 702 | - | linker |
| Asn 703 | - | linker |
| Ser 704 | - | linker |
| Gly 705 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 709 | - | expression tag |
| Gly 710 | - | expression tag |
| Gly 711 | - | expression tag |
| Arg 965 | Lys 965 | engineered mutation |
| Gln 1052 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Arg 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 496557.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2362.6 | |
| All* | Total formula weight | 498920.3 |
