8BN8
METTL3-METTL14 heterodimer bound to the SAM competitive small molecule inhibitor STM3006
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | AAA | N6-adenosine-methyltransferase catalytic subunit | polymer | 218 | 25057.8 | 1 | UniProt (Q86U44) Pfam (PF05063) In PDB | Homo sapiens (human) | Methyltransferase-like protein 3,hMETTL3,N6-adenosine-methyltransferase 70 kDa subunit,MT-A70 |
| 2 | BBB | N6-adenosine-methyltransferase non-catalytic subunit | polymer | 291 | 33634.2 | 1 | UniProt (Q9HCE5) Pfam (PF05063) In PDB | Homo sapiens (human) | Methyltransferase-like protein 14,hMETTL14 |
| 3 | AAA | 2-[[4-(6-bromanyl-2~{H}-indazol-4-yl)-1,2,3-triazol-1-yl]methyl]-6-[(4,4-dimethylpiperidin-1-yl)methyl]imidazo[1,2-a]pyridine | non-polymer | 519.4 | 1 | Chemie (QWR) | |||
| 4 | water | water | 18.0 | 83 | Chemie (HOH) |
Sequence modifications
BBB: 107 - 395 (UniProt: Q9HCE5)
| PDB | External Database | Details |
|---|---|---|
| Gly 105 | - | expression tag |
| Ser 106 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 58692.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 519.4 | |
| All* | Total formula weight | 59211.4 |
