8BM2
Crystal structure of JAK2 JH1 in complex with gandotinib
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein kinase JAK2 | polymer | 317 | 37325.3 | 2 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (human) | Janus kinase 2,JAK-2 |
2 | A, B | 3-[(4-chloranyl-2-fluoranyl-phenyl)methyl]-2-methyl-~{N}-(5-methyl-1~{H}-pyrazol-3-yl)-8-(morpholin-4-ylmethyl)imidazo[1,2-b]pyridazin-6-amine | non-polymer | 469.9 | 2 | Chemie (QQC) | |||
3 | water | water | 18.0 | 513 | Chemie (HOH) |
Sequence modifications
A, B: 840 - 1132 (UniProt: O60674)
PDB | External Database | Details |
---|---|---|
Met 816 | - | initiating methionine |
Gly 817 | - | expression tag |
His 818 | - | expression tag |
His 819 | - | expression tag |
His 820 | - | expression tag |
His 821 | - | expression tag |
His 822 | - | expression tag |
His 823 | - | expression tag |
Ser 824 | - | expression tag |
Ser 825 | - | expression tag |
Gly 826 | - | expression tag |
Val 827 | - | expression tag |
Asp 828 | - | expression tag |
Leu 829 | - | expression tag |
Gly 830 | - | expression tag |
Thr 831 | - | expression tag |
Glu 832 | - | expression tag |
Asn 833 | - | expression tag |
Leu 834 | - | expression tag |
Tyr 835 | - | expression tag |
Phe 836 | - | expression tag |
Gln 837 | - | expression tag |
Ser 838 | - | expression tag |
Met 839 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 74650.7 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 939.9 | |
All* | Total formula weight | 75590.6 |