8BHS
GABA-A receptor a5 homomer - a5V3 - RO4938581
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Gamma-aminobutyric acid receptor subunit alpha-5 | polymer | 360 | 41057.9 | 5 | UniProt (P31644) Pfam (PF02931) Pfam (PF02932) | Homo sapiens (human) | GABA(A) receptor subunit alpha-5 |
| 2 | F, H, J, L, N (A, B, C, D, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 3 | G, I, K, M, O (A, B, C, D, E) | 5-[bis(fluoranyl)methyl]-15-bromanyl-2,4,8,9,11-pentazatetracyclo[11.4.0.0^{2,6}.0^{8,12}]heptadeca-1(13),3,5,9,11,14,16-heptaene | non-polymer | 352.1 | 5 | Chemie (QK9) |
Sequence modifications
A, B, C, D, E: 1 - 315 (UniProt: P31644)
A, B, C, D, E: 393 - 419 (UniProt: P31644)
| PDB | External Database | Details |
|---|---|---|
| Met 48 | Ile 79 | engineered mutation |
| Asn 51 | Thr 82 | engineered mutation |
| Ile 67 | Val 98 | engineered mutation |
| Ala 70 | Arg 101 | engineered mutation |
| Thr 72 | Ser 103 | engineered mutation |
| Phe 111 | Ile 142 | engineered mutation |
| Trp 114 | Asn 145 | engineered mutation |
| Arg 120 | Lys 151 | engineered mutation |
| Met 121 | Leu 152 | engineered mutation |
| Ile 124 | Leu 155 | engineered mutation |
| Trp 125 | Glu 156 | engineered mutation |
| Asn 126 | Asp 157 | engineered mutation |
| Arg 129 | Thr 160 | engineered mutation |
| Val 130 | Leu 161 | engineered mutation |
| Leu 134 | Met 165 | engineered mutation |
| Asp 145 | Gln 176 | engineered mutation |
| Glu 153 | Ala 184 | engineered mutation |
| Gln 154 | His 185 | engineered mutation |
| Asn 155 | Ala 186 | engineered mutation |
| Ala 256 | Pro 287 | engineered mutation |
| Leu 305 | Ile 336 | engineered mutation |
| Phe 309 | Thr 340 | engineered mutation |
| Ile 313 | Phe 344 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ser 316 | - | linker |
| Gln 317 | - | linker |
| Pro 318 | - | linker |
| Ala 319 | - | linker |
| Arg 320 | - | linker |
| Ala 321 | - | linker |
| Ala 322 | - | linker |
| Ile 404 | Val 435 | engineered mutation |
| Gly 420 | - | expression tag |
| Thr 421 | - | expression tag |
| Thr 422 | - | expression tag |
| Glu 423 | - | expression tag |
| Thr 424 | - | expression tag |
| Ser 425 | - | expression tag |
| Gln 426 | - | expression tag |
| Val 427 | - | expression tag |
| Ala 428 | - | expression tag |
| Pro 429 | - | expression tag |
| Ala 430 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 205289.6 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2866.7 | |
| All* | Total formula weight | 208156.3 |
