8BHQ
GABA-A receptor a5 homomer - a5V3 - RO7172670
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E | Gamma-aminobutyric acid receptor subunit alpha-5 | polymer | 360 | 41057.9 | 5 | UniProt (P31644) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (human) | GABA(A) receptor subunit alpha-5 |
| 2 | A, B, C, D, E | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 3 | A, B, C, D, E | 2-[[5-methyl-3-(6-methylpyridazin-3-yl)-1,2-oxazol-4-yl]methyl]-5-(5-oxa-2-azaspiro[3.5]nonan-2-yl)pyridazin-3-one | non-polymer | 408.5 | 5 | Chemie (QR3) |
Sequence modifications
A, B, C, D, E: 1 - 284 (UniProt: P31644)
A, B, C, D, E: 393 - 419 (UniProt: P31644)
| PDB | External Database | Details |
|---|---|---|
| Met 48 | Ile 79 | engineered mutation |
| Asn 51 | Thr 82 | engineered mutation |
| Ile 67 | Val 98 | engineered mutation |
| Ala 70 | Arg 101 | engineered mutation |
| Thr 72 | Ser 103 | engineered mutation |
| Phe 111 | Ile 142 | engineered mutation |
| Trp 114 | Asn 145 | engineered mutation |
| Arg 120 | Lys 151 | engineered mutation |
| Met 121 | Leu 152 | engineered mutation |
| Ile 124 | Leu 155 | engineered mutation |
| Trp 125 | Glu 156 | engineered mutation |
| Asn 126 | Asp 157 | engineered mutation |
| Arg 129 | Thr 160 | engineered mutation |
| Val 130 | Leu 161 | engineered mutation |
| Leu 134 | Met 165 | engineered mutation |
| Asp 145 | Gln 176 | engineered mutation |
| Glu 153 | Ala 184 | engineered mutation |
| Gln 154 | His 185 | engineered mutation |
| Asn 155 | Ala 186 | engineered mutation |
| Ala 256 | Pro 287 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Tyr 285 | - | linker |
| Ala 286 | - | linker |
| Thr 287 | - | linker |
| Ala 288 | - | linker |
| Met 289 | - | linker |
| Asp 290 | - | linker |
| Trp 291 | - | linker |
| Phe 292 | - | linker |
| Ile 293 | - | linker |
| Ala 294 | - | linker |
| Val 295 | - | linker |
| Cys 296 | - | linker |
| Tyr 297 | - | linker |
| Ala 298 | - | linker |
| Phe 299 | - | linker |
| Val 300 | - | linker |
| Phe 301 | - | linker |
| Ser 302 | - | linker |
| Ala 303 | - | linker |
| Leu 304 | - | linker |
| Leu 305 | - | linker |
| Glu 306 | - | linker |
| Phe 307 | - | linker |
| Ala 308 | - | linker |
| Phe 309 | - | linker |
| Val 310 | - | linker |
| Asn 311 | - | linker |
| Tyr 312 | - | linker |
| Ile 313 | - | linker |
| Thr 314 | - | linker |
| Lys 315 | - | linker |
| Ser 316 | - | linker |
| Gln 317 | - | linker |
| Pro 318 | - | linker |
| Ala 319 | - | linker |
| Arg 320 | - | linker |
| Ala 321 | - | linker |
| Ala 322 | - | linker |
| Ile 404 | Val 435 | engineered mutation |
| Gly 420 | - | expression tag |
| Thr 421 | - | expression tag |
| Thr 422 | - | expression tag |
| Glu 423 | - | expression tag |
| Thr 424 | - | expression tag |
| Ser 425 | - | expression tag |
| Gln 426 | - | expression tag |
| Val 427 | - | expression tag |
| Ala 428 | - | expression tag |
| Pro 429 | - | expression tag |
| Ala 430 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 205289.6 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 3148.3 | |
| All* | Total formula weight | 208437.9 |
