8BHM
GABA-A receptor a5 homomer - a5V3 - DMCM
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E | Gamma-aminobutyric acid receptor subunit alpha-5 | polymer | 360 | 41057.9 | 5 | UniProt (P31644) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (human) | GABA(A) receptor subunit alpha-5 |
2 | A, B, C, D, E | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
3 | A, B, C, D, E | methyl 4-ethyl-6,7-dimethoxy-9H-pyrido[3,4-b]indole-3-carboxylate | non-polymer | 314.3 | 5 | Chemie (R63) |
Sequence modifications
A, B, C, D, E: 1 - 284 (UniProt: P31644)
A, B, C, D, E: 393 - 419 (UniProt: P31644)
PDB | External Database | Details |
---|---|---|
Met 48 | Ile 79 | engineered mutation |
Asn 51 | Thr 82 | engineered mutation |
Ile 67 | Val 98 | engineered mutation |
Ala 70 | Arg 101 | engineered mutation |
Thr 72 | Ser 103 | engineered mutation |
Phe 111 | Ile 142 | engineered mutation |
Trp 114 | Asn 145 | engineered mutation |
Arg 120 | Lys 151 | engineered mutation |
Met 121 | Leu 152 | engineered mutation |
Ile 124 | Leu 155 | engineered mutation |
Trp 125 | Glu 156 | engineered mutation |
Asn 126 | Asp 157 | engineered mutation |
Arg 129 | Thr 160 | engineered mutation |
Val 130 | Leu 161 | engineered mutation |
Leu 134 | Met 165 | engineered mutation |
Asp 145 | Gln 176 | engineered mutation |
Glu 153 | Ala 184 | engineered mutation |
Gln 154 | His 185 | engineered mutation |
Asn 155 | Ala 186 | engineered mutation |
Ala 256 | Pro 287 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Tyr 285 | - | linker |
Ala 286 | - | linker |
Thr 287 | - | linker |
Ala 288 | - | linker |
Met 289 | - | linker |
Asp 290 | - | linker |
Trp 291 | - | linker |
Phe 292 | - | linker |
Ile 293 | - | linker |
Ala 294 | - | linker |
Val 295 | - | linker |
Cys 296 | - | linker |
Tyr 297 | - | linker |
Ala 298 | - | linker |
Phe 299 | - | linker |
Val 300 | - | linker |
Phe 301 | - | linker |
Ser 302 | - | linker |
Ala 303 | - | linker |
Leu 304 | - | linker |
Leu 305 | - | linker |
Glu 306 | - | linker |
Phe 307 | - | linker |
Ala 308 | - | linker |
Phe 309 | - | linker |
Val 310 | - | linker |
Asn 311 | - | linker |
Tyr 312 | - | linker |
Ile 313 | - | linker |
Thr 314 | - | linker |
Lys 315 | - | linker |
Ser 316 | - | linker |
Gln 317 | - | linker |
Pro 318 | - | linker |
Ala 319 | - | linker |
Arg 320 | - | linker |
Ala 321 | - | linker |
Ala 322 | - | linker |
Ile 404 | Val 435 | engineered mutation |
Gly 420 | - | expression tag |
Thr 421 | - | expression tag |
Thr 422 | - | expression tag |
Glu 423 | - | expression tag |
Thr 424 | - | expression tag |
Ser 425 | - | expression tag |
Gln 426 | - | expression tag |
Val 427 | - | expression tag |
Ala 428 | - | expression tag |
Pro 429 | - | expression tag |
Ala 430 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 205289.6 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 2677.7 | |
All* | Total formula weight | 207967.3 |