8BE7

Crystal structure of SOS1-HRas-peptidomimetic3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (R)	GTPase HRas	polymer	186	21046.6	1	UniProt (P01112) Pfam (PF00071)	Homo sapiens (human)	H-Ras-1,Ha-Ras,Transforming protein p21,c-H-ras,p21ras
2	B (S)	Son of sevenless homolog 1	polymer	507	59348.8	1	UniProt (Q07889) Pfam (PF00618) Pfam (PF00617)	Homo sapiens (human)	SOS-1
3	C (P)	SOS1-HRas-peptidomimetic3	polymer	9	1097.2	1		Synthetic construct
4	D, E (R, S)	water	water		18.0	6	Chemie (HOH)

Sequence modifications

R: 1 - 166 (UniProt: P01112)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag

S: 564 - 1049 (UniProt: Q07889)

PDB	External Database	Details
Met 543	-	initiating methionine
Gly 544	-	expression tag
Ser 545	-	expression tag
Ser 546	-	expression tag
His 547	-	expression tag
His 548	-	expression tag
His 549	-	expression tag
His 550	-	expression tag
His 551	-	expression tag
His 552	-	expression tag
Ser 553	-	expression tag
Ser 554	-	expression tag
Gly 555	-	expression tag
Leu 556	-	expression tag
Val 557	-	expression tag
Pro 558	-	expression tag
Arg 559	-	expression tag
Gly 560	-	expression tag
Ser 561	-	expression tag
His 562	-	expression tag
Met 563	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	81492.6
All*	Total formula weight	81492.6

*Water molecules are not included.