8BDM

VCB in complex with compound 26

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G, J (G, D, A, J)	Elongin-B	polymer	104	11852.4	4	UniProt (Q15370) Pfam (PF00240)	Homo sapiens (human)	EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2
2	B, E, H, K (H, E, B, K)	Elongin-C	polymer	97	10974.6	4	UniProt (Q15369) Pfam (PF03931)	Homo sapiens (human)	EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1
3	C, F, I, L (I, F, C, L)	von Hippel-Lindau disease tumor suppressor	polymer	162	18806.3	4	UniProt (P40337) Pfam (PF01847) Pfam (PF17211)	Homo sapiens (human)	Protein G7,pVHL
4	M, N, O, P (I, F, C, L)	(2~{S},4~{R})-~{N}-[[2-(2-methoxyethoxy)-4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]-1-[(2~{R})-3-methyl-2-(3-methyl-1,2-oxazol-5-yl)butanoyl]-4-oxidanyl-pyrrolidine-2-carboxamide	non-polymer		556.7	4	Chemie (QE9)
5	AA, BA, Q, R, S... (K, L, G, H, I...)	water	water		18.0	769	Chemie (HOH)

Sequence modifications

H, E, B, K: 17 - 112 (UniProt: Q15369)

PDB	External Database	Details
Met 16	-	initiating methionine

I, F, C, L: 54 - 213 (UniProt: P40337)

PDB	External Database	Details
Gly 52	-	expression tag
Ser 53	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	166533.1
Non-Polymers*	Number of molecules	4
	Total formula weight	2226.7
All*	Total formula weight	168759.8

*Water molecules are not included.