8BDE

Tubulin-baccatin III complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Tubulin alpha-1B chain	polymer	451	50204.4	2	UniProt (P81947) Pfam (PF00091) Pfam (PF03953)	Bos taurus (cattle)	Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain
2	B, D (B, D)	Tubulin beta-2B chain	polymer	445	49999.9	2	UniProt (Q6B856) Pfam (PF00091) Pfam (PF03953)	Bos taurus (cattle)
3	E (E)	Stathmin-4	polymer	143	16844.2	1	UniProt (P63043) Pfam (PF00836)	Rattus norvegicus (Norway rat)	Stathmin-like protein B3,RB3
4	F (F)	Tubulin beta-2B chain	polymer	384	44378.5	1	UniProt (E1BQ43)	Gallus gallus (chicken)
5	G, M (A, C)	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	2	Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466)
6	H, K, N, Q, S (A, B, C, D, F)	MAGNESIUM ION	non-polymer		24.3	5	Chemie (MG) PubChem (888)
7	I, O (A, C)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA) PubChem (271)
8	J, P (B, D)	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537)
9	L (B)	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	1	Chemie (MES) PubChem (4478249)
10	R (D)	[(1~{S},2~{S},3~{R},4~{S},7~{R},9~{S},10~{S},12~{R},15~{S})-4,12-diacetyloxy-10,14,16,16-tetramethyl-1,9,15-tris(oxidanyl)-11-oxidanylidene-6-oxatetracyclo[11.3.1.0^{3,10}.0^{4,7}]heptadec-13-en-2-yl] benzoate	non-polymer		586.6	1	Chemie (R3Q) PubChem (65366) PubChem (4357887) PubChem (5321416) PubChem (6713218) PubChem (9938327) PubChem (11103870) PubChem (11970037) PubChem (14476343) PubChem (23307885) PubChem (23636617) PubChem (25199938) PubChem (45138816) PubChem (45360039) PubChem (16757809) PubChem (21992969) PubChem (25200042) PubChem (49827070) PubChem (53298528) PubChem (2733529) PubChem (332624) PubChem (71816153) PubChem (92222536) PubChem (92222534) PubChem (101406648) PubChem (53783414) PubChem (7157253) PubChem (125039681) PubChem (11886864) PubChem (58003697) PubChem (138107788) PubChem (141815690) PubChem (58633655) PubChem (58651585) PubChem (163852439) PubChem (168012170) PubChem (59904713) PubChem (59997513) PubChem (92222535) PubChem (92222537) PubChem (101425797) PubChem (125039678) PubChem (125039679) PubChem (125039680) PubChem (126550706) PubChem (140434581) PubChem (141811074) PubChem (146158451) PubChem (155082827) PubChem (160849767) PubChem (163066865) PubChem (163066866) PubChem (163066867) PubChem (163285056) PubChem (163852440) PubChem (170689685) PubChem (172428972)
11	T (F)	PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER	non-polymer		505.2	1	Chemie (ACP) PubChem (4799) PubChem (46936826) PubChem (91532) PubChem (91885473) PubChem (157749842) PubChem (134943439) PubChem (157749839)
12	U, V, W, X, Y... (A, B, C, D, E...)	water	water		18.0	859	Chemie (HOH)

Sequence modifications

E: 5 - 145 (UniProt: P63043)

PDB	External Database	Details
Met 3	-	initiating methionine
Ala 4	-	expression tag

F: 1 - 378 (UniProt: E1BQ43)

PDB	External Database	Details
His 379	-	expression tag
His 380	-	expression tag
His 381	-	expression tag
His 382	-	expression tag
His 383	-	expression tag
His 384	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	261631.3
Non-Polymers*	Number of molecules	14
	Total formula weight	3421.5
All*	Total formula weight	265052.8

*Water molecules are not included.