8BC9

Human Brr2 Helicase Region in complex with C-tail deleted Jab1 and compound 24

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B	U5 small nuclear ribonucleoprotein 200 kDa helicase	polymer	1747	199666.7	1	UniProt (O75643) Pfam (PF00270) Pfam (PF00271) Pfam (PF02889) In PDB	Homo sapiens (human)	Activating signal cointegrator 1 complex subunit 3-like 1,BRR2 homolog,U5 snRNP-specific 200 kDa protein,U5-200KD
2	J	Pre-mRNA-processing-splicing factor 8	polymer	263	30133.2	1	UniProt (Q6P2Q9) Pfam (PF01398) Pfam (PF08084) In PDB	Homo sapiens (human)	220 kDa U5 snRNP-specific protein,PRP8 homolog,Splicing factor Prp8,p220
3	B	N-hydroxybenzenesulfonamide	non-polymer		173.2	1	Chemie (A09)
4	B, J	1,2-ETHANEDIOL	non-polymer		62.1	11	Chemie (EDO)
5		water	water		18.0	418	Chemie (HOH)

Sequence modifications

B: 394 - 2136 (UniProt: O75643)

PDB	External Database	Details
Gly 390	-	expression tag
Ala 391	-	expression tag
Glu 392	-	expression tag
Phe 393	-	expression tag

J: 2064 - 2320 (UniProt: Q6P2Q9)

PDB	External Database	Details
Gly 2058	-	expression tag
Pro 2059	-	expression tag
Leu 2060	-	expression tag
Gly 2061	-	expression tag
Ser 2062	-	expression tag
Met 2063	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	229799.9
Non-Polymers*	Number of molecules	12
	Total formula weight	855.9
All*	Total formula weight	230655.8

*Water molecules are not included.