8B91
Crystal structure of mutant PPARG (C313A) and NCOR2 with an inverse agonist (compound SI-1)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Peroxisome proliferator-activated receptor gamma | polymer | 279 | 31830.9 | 2 | UniProt (P37231) Pfam (PF00104) In PDB | Homo sapiens (human) | PPAR-gamma,Nuclear receptor subfamily 1 group C member 3 |
| 2 | C, D | Nuclear receptor corepressor 2 | polymer | 23 | 2638.1 | 2 | UniProt (Q9Y618) In PDB | Homo sapiens | N-CoR2,CTG repeat protein 26,SMAP270,Silencing mediator of retinoic acid and thyroid hormone receptor,SMRT,T3 receptor-associating factor,TRAC,Thyroid-,retinoic-acid-receptor-associated corepressor |
| 3 | A | ~{N}3-[4-[bis(fluoranyl)methoxy]-3-fluoranyl-phenyl]-4-chloranyl-6-fluoranyl-~{N}1-[(2-methoxyphenyl)methyl]benzene-1,3-dicarboxamide | non-polymer | 496.8 | 1 | Chemie (Q4O) | |||
| 4 | water | water | 18.0 | 197 | Chemie (HOH) |
Sequence modifications
A, B: 203 - 477 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Gly 199 | - | expression tag |
| Ser 200 | - | expression tag |
| His 201 | - | expression tag |
| Met 202 | - | expression tag |
| Ala 285 | Cys 313 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 68938.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 496.8 | |
| All* | Total formula weight | 69434.8 |
