8B8N

Crystal structure of JAK2 JH2-V617F in complex with Cdk2 inhibitor IV

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Tyrosine-protein kinase JAK2	polymer	289	33169.0	1	UniProt (O60674) Pfam (PF07714)	Homo sapiens (human)	Janus kinase 2,JAK-2
2	B, C, D (A)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
3	E (A)	4-{[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino}-N,N-diethylbenzamide	non-polymer		422.5	1	Chemie (AQG)
4	F (A)	water	water		18.0	65	Chemie (HOH)

Sequence modifications

A: 536 - 812 (UniProt: O60674)

PDB	External Database	Details
Phe 617	Val 617	variant
Ala 659	Trp 659	engineered mutation
Ala 777	Trp 777	engineered mutation
His 794	Phe 794	engineered mutation
Leu 813	-	expression tag
Val 814	-	expression tag
Pro 815	-	expression tag
Arg 816	-	expression tag
Gly 817	-	expression tag
Ser 818	-	expression tag
His 819	-	expression tag
His 820	-	expression tag
His 821	-	expression tag
His 822	-	expression tag
His 823	-	expression tag
His 824	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33169.0
Non-Polymers*	Number of molecules	4
	Total formula weight	698.8
All*	Total formula weight	33867.8

*Water molecules are not included.