8B8M
Cryo-EM structure of Ca2+-bound mTMEM16F N562A mutant in Digitonin open/closed
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Anoctamin-6 | polymer | 975 | 113420.6 | 2 | UniProt (Q6P9J9) Pfam (PF16178) Pfam (PF04547) | Mus musculus (house mouse) | Small-conductance calcium-activated nonselective cation channel,SCAN channel,Transmembrane protein 16F |
| 2 | C, D, E, F, G... (A, B) | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) |
Sequence modifications
A, B: 1 - 911 (UniProt: Q6P9J9)
| PDB | External Database | Details |
|---|---|---|
| Ala 562 | Asn 562 | engineered mutation |
| Ala 912 | - | expression tag |
| Leu 913 | - | expression tag |
| Glu 914 | - | expression tag |
| Val 915 | - | expression tag |
| Leu 916 | - | expression tag |
| Phe 917 | - | expression tag |
| Gln 918 | - | expression tag |
| Gly 919 | - | expression tag |
| Pro 920 | - | expression tag |
| Gln 921 | - | expression tag |
| Gly 922 | - | expression tag |
| Thr 923 | - | expression tag |
| Glu 924 | - | expression tag |
| Gln 925 | - | expression tag |
| Lys 926 | - | expression tag |
| Leu 927 | - | expression tag |
| Ile 928 | - | expression tag |
| Ser 929 | - | expression tag |
| Glu 930 | - | expression tag |
| Glu 931 | - | expression tag |
| Asp 932 | - | expression tag |
| Leu 933 | - | expression tag |
| Arg 934 | - | expression tag |
| Gly 935 | - | expression tag |
| Ala 936 | - | expression tag |
| Ser 937 | - | expression tag |
| Met 938 | - | expression tag |
| Asp 939 | - | expression tag |
| Glu 940 | - | expression tag |
| Lys 941 | - | expression tag |
| Thr 942 | - | expression tag |
| Thr 943 | - | expression tag |
| Gly 944 | - | expression tag |
| Trp 945 | - | expression tag |
| Arg 946 | - | expression tag |
| Gly 947 | - | expression tag |
| Gly 948 | - | expression tag |
| His 949 | - | expression tag |
| Val 950 | - | expression tag |
| Val 951 | - | expression tag |
| Glu 952 | - | expression tag |
| Gly 953 | - | expression tag |
| Leu 954 | - | expression tag |
| Ala 955 | - | expression tag |
| Gly 956 | - | expression tag |
| Glu 957 | - | expression tag |
| Leu 958 | - | expression tag |
| Glu 959 | - | expression tag |
| Gln 960 | - | expression tag |
| Leu 961 | - | expression tag |
| Arg 962 | - | expression tag |
| Ala 963 | - | expression tag |
| Arg 964 | - | expression tag |
| Leu 965 | - | expression tag |
| Glu 966 | - | expression tag |
| His 967 | - | expression tag |
| His 968 | - | expression tag |
| Pro 969 | - | expression tag |
| Gln 970 | - | expression tag |
| Gly 971 | - | expression tag |
| Gln 972 | - | expression tag |
| Arg 973 | - | expression tag |
| Glu 974 | - | expression tag |
| Pro 975 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 226841.2 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 240.5 | |
| All* | Total formula weight | 227081.7 |
