8B4X

X-ray structure of furin (PCSK3) in complex with Guanidinomethyl-Phac-R-Tle-K-6-(aminomethyl)-3-amino-isoindol

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Furin	polymer	480	52112.3	1	UniProt (P09958) Pfam (PF00082) Pfam (PF01483)	Homo sapiens (human)	Dibasic-processing enzyme,Paired basic amino acid residue-cleaving enzyme,PACE
2	B (B)	Guanidinomethyl-Phac-R-Tle-K-6-(aminomethyl)-3-amino-isoindol	polymer	5	751.0	1		synthetic construct
3	C, D, E (A)	CALCIUM ION	non-polymer		40.1	3	Chemie (CA)
4	F, G, H, I (A)	SODIUM ION	non-polymer		23.0	4	Chemie (NA)
5	J (A)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
6	K, L (A)	DIMETHYL SULFOXIDE	non-polymer		78.1	2	Chemie (DMS)
7	M, N (A, B)	water	water		18.0	455	Chemie (HOH)

Sequence modifications

A: 108 - 574 (UniProt: P09958)

PDB	External Database	Details
Ser 575	-	expression tag
Gly 576	-	expression tag
Ser 577	-	expression tag
Leu 578	-	expression tag
Val 579	-	expression tag
Pro 580	-	expression tag
Arg 581	-	expression tag
Gly 582	-	expression tag
Ser 583	-	expression tag
His 584	-	expression tag
His 585	-	expression tag
His 586	-	expression tag
His 587	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	52863.3
Non-Polymers*	Number of molecules	10
	Total formula weight	403.9
All*	Total formula weight	53267.2

*Water molecules are not included.