8AZR

KRAS in complex with precursor 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	GTPase KRas	polymer	170	19312.7	1	UniProt (P01116) Pfam (PF00071) In PDB	Homo sapiens (human)	K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras
2	A	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	1	Chemie (GDP)
3	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
4	A	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
5	A	(4~{S})-2-azanyl-4-[3-[6-[(2~{S})-2,4-dimethylpiperazin-1-yl]pyridin-2-yl]-1,2,4-oxadiazol-5-yl]-4-methyl-6,7-dihydro-5~{H}-1-benzothiophene-3-carbonitrile	non-polymer		449.6	1	Chemie (LR4)
6		water	water		18.0	303	Chemie (HOH)

Sequence modifications

A: 1 - 164 (UniProt: P01116)

PDB	External Database	Details
Gly 0	-	expression tag
Ser 118	Cys 118	engineered mutation
Gly 151	Arg 151	engineered mutation
Asp 153	Glu 153	engineered mutation
Lys 165	-	expression tag
His 166	-	expression tag
Lys 167	-	expression tag
Glu 168	-	expression tag
Lys 169	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	19312.7
Non-Polymers*	Number of molecules	4
	Total formula weight	979.1
All*	Total formula weight	20291.9

*Water molecules are not included.