8AYM

Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-55511118

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, F (I, J)	Voltage-dependent calcium channel gamma-8 subunit	polymer	423	43576.0	2	UniProt (Q8VHW5) Pfam (PF00822)	Rattus norvegicus (Norway rat)	Neuronal voltage-gated calcium channel gamma-8 subunit,Transmembrane AMPAR regulatory protein gamma-8,TARP gamma-8
2	B, E (C, A)	Isoform Flip of Glutamate receptor 1	polymer	915	102661.9	2	UniProt (P19490) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060)	Rattus norvegicus (Norway rat)	GluR-1,AMPA-selective glutamate receptor 1,GluR-A,GluR-K1,Glutamate receptor ionotropic,AMPA 1,GluA1
3	C, D (D, B)	Isoform Flip of Glutamate receptor 2	polymer	860	96247.1	2	UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060)	Rattus norvegicus (Norway rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
4	G, HA (I, J)	6-[2-chloro-6-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-ol	non-polymer		328.7	2	Chemie (XVD)
5	BA, CA, EA, FA, GA... (A, J, I, C, D...)	PALMITIC ACID	non-polymer		256.4	14	Chemie (PLM)
6	I, P, U, Z (C, D, B, A)	{[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid	non-polymer		409.3	4	Chemie (ZK1)
7	AA, DA, J, M, T... (A, C, D, B)	(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate	non-polymer		760.1	6	Chemie (POV)
8	Q, V (D, B)	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate	non-polymer		356.5	2	Chemie (OLC)

Sequence modifications

I, J: 2 - 417 (UniProt: Q8VHW5)

PDB	External Database	Details
Gly 1	-	expression tag
Leu 418	-	expression tag
Glu 419	-	expression tag
Val 420	-	expression tag
Leu 421	-	expression tag
Phe 422	-	expression tag
Gln 423	-	expression tag

C, A: -25 - 889 (UniProt: P19490)

PDB	External Database	Details
Asp -6	-	insertion
Tyr -5	-	insertion
Lys -4	-	insertion
Asp -3	-	insertion
Asp -2	-	insertion
Asp -1	-	insertion
Asp 0	-	insertion
Lys 1	-	insertion

D, B: -20 - 839 (UniProt: P19491)

PDB	External Database	Details
Arg 586	Gln 607	variant

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	484970.0
Non-Polymers*	Number of molecules	28
	Total formula weight	11157.8
All*	Total formula weight	496127.8

*Water molecules are not included.