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8AYH

Structure of Complement C5 in Complex with small molecule inhibitor and CVF

Replaces:  6I2X
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(C)
Complement C5 beta chainpolymer65773615.81UniProt (P01031)
Pfam (PF17790)
Pfam (PF01835)
Pfam (PF17791)
Pfam (PF17789)
Pfam (PF07703)
Homo sapiens (human)
2B
(A)
Complement C5 alpha chainpolymer999112635.01UniProt (P01031)
Pfam (PF01821)
Pfam (PF00207)
Pfam (PF07678)
Pfam (PF21309)
Pfam (PF07677)
Pfam (PF01759)
Homo sapiens (human)
3C
(B)
Cobra venom factorpolymer1642184726.71UniProt (Q91132)
Pfam (PF17789)
Pfam (PF07703)
Pfam (PF01821)
Pfam (PF00207)
Pfam (PF21406)
Pfam (PF07678)
Pfam (PF21308)
Pfam (PF07677)
Pfam (PF01759)
Pfam (PF17790)
Pfam (PF01835)
Pfam (PF17791)
Naja kaouthia (monocled cobra)CVFk,Complement C3 homolog
4D
(A)
5-methoxy-2-[[(1~{S})-1-(2-methoxyphenyl)ethyl]carbamoylamino]-4-(4-methylpentoxy)benzoic acidnon-polymer444.51Chemie (H1H)
5E
(B)
MAGNESIUM IONnon-polymer24.31Chemie (MG)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight370977.5
Non-Polymers*Number of molecules2
Total formula weight468.8
All*Total formula weight371446.3
*Water molecules are not included.

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PDB entries from 2025-06-11

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