8AXH
Crystal structure of a MUC1-like glycopeptide containing the unnatural L-4-hydroxynorvaline in complex with scFv-SM3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | Single-chain variable antibody (scFv) SM3 | polymer | 244 | 25758.3 | 1 | Mus musculus | ||
| 2 | B (A) | Mucin-1 subunit alpha | polymer | 7 | 668.7 | 1 | UniProt (P15941) | Homo sapiens | MUC1-NT,MUC1-alpha |
| 3 | C, D, E, F, G... (H, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 4 | H (A) | 2-acetamido-2-deoxy-alpha-D-galactopyranose | non-polymer | 221.2 | 1 | Chemie (A2G) | |||
| 5 | J, K (H, A) | water | water | 18.0 | 178 | Chemie (HOH) |
Sequence modifications
A: 1 - 7 (UniProt: P15941)
| PDB | External Database | Details |
|---|---|---|
| Vah 4 | Thr 144 | engineered mutation |
| Nh2 8 | - | amidation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 26427.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 593.6 | |
| All* | Total formula weight | 27020.7 |
