8AX3

Structure of recombinant human beta-glucocerebrosidase in complex with L-carbaxylosyl fluoride

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Lysosomal acid glucosylceramidase	polymer	497	55659.2	2	UniProt (P04062) Pfam (PF02055) Pfam (PF17189) In PDB	Homo sapiens (human)	Lysosomal acid GCase,Acid beta-glucosidase,Alglucerase,Beta-glucocerebrosidase,Beta-GC,Cholesterol glucosyltransferase,SGTase,Cholesteryl-beta-glucosidase,D-glucosyl-N-acylsphingosine glucohydrolase,Imiglucerase
2	C, D	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
3	E	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	A, B	SULFATE ION	non-polymer		96.1	6	Chemie (SO4)
5	A, B	1,2-ETHANEDIOL	non-polymer		62.1	47	Chemie (EDO)
6	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
7	A, B	(1~{S},2~{R},3~{S},6~{S})-6-fluoranylcyclohex-4-ene-1,2,3-triol	non-polymer		148.1	4	Chemie (OD0)
8	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
9	B	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
10	B	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
11		water	water		18.0	893	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	111318.4
Branched	Number of molecules	3
	Total formula weight	1597.5
Non-Polymers*	Number of molecules	62
	Total formula weight	4683.7
All*	Total formula weight	117599.6

*Water molecules are not included.