8AX3
Structure of recombinant human beta-glucocerebrosidase in complex with L-carbaxylosyl fluoride
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Lysosomal acid glucosylceramidase | polymer | 497 | 55659.2 | 2 | UniProt (P04062) Pfam (PF02055) Pfam (PF17189) | Homo sapiens (human) | Lysosomal acid GCase,Acid beta-glucosidase,Alglucerase,Beta-glucocerebrosidase,Beta-GC,Cholesterol glucosyltransferase,SGTase,Cholesteryl-beta-glucosidase,D-glucosyl-N-acylsphingosine glucohydrolase,Imiglucerase |
| 2 | C, D (C, D) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 3 | E (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | F, G, JA, MA, R... (A, B) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 5 | AA, AB, BA, BB, CA... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 47 | Chemie (EDO) | |||
| 6 | O, VA (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 7 | T, W, XA, YA (A, B) | (1~{S},2~{R},3~{S},6~{S})-6-fluoranylcyclohex-4-ene-1,2,3-triol | non-polymer | 148.1 | 4 | Chemie (OD0) | |||
| 8 | IA (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 9 | EB (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 10 | OB (B) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 11 | PB, QB (A, B) | water | water | 18.0 | 893 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 111318.4 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1597.5 | |
| Non-Polymers* | Number of molecules | 62 |
| Total formula weight | 4683.7 | |
| All* | Total formula weight | 117599.6 |
