8ASF

Crystal structure of Thrombin in complex with macrocycle T1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (L, A)	Thrombin light chain	polymer	36	4096.5	2	UniProt (P00734) Pfam (PF09396)	Homo sapiens (human)
2	B, D (H, B)	Thrombin heavy chain	polymer	259	29780.2	2	UniProt (P00734) Pfam (PF00089)	Homo sapiens (human)
3	E, F (H, B)	5-chloranyl-~{N}-[[(9~{S},15~{R})-8,14,17-tris(oxidanylidene)-3,20-dithia-7,13,16-triazatetracyclo[20.2.2.1^{5,7}.1^{9,13}]octacosa-1(25),22(26),23-trien-15-yl]methyl]thiophene-2-carboxamide	non-polymer		635.3	2	Chemie (NWF)
4	G, H, I, J (L, H, A, B)	water	water		18.0	59	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	67753.5
Non-Polymers*	Number of molecules	2
	Total formula weight	1270.5
All*	Total formula weight	69024.0

*Water molecules are not included.