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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8AQS

BA.4/5 SARS-CoV-2 Spike bound to human ACE2 (local)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Spike glycoprotein,Fibritinpolymer1288142688.11UniProt (P0DTC2)
UniProt (P10104)
Pfam (PF07921)		Severe acute respiratory syndrome coronavirus 2S glycoprotein,E2,Peplomer protein,Collar protein,Whisker antigen control protein
2B
(B)		Processed angiotensin-converting enzyme 2polymer886101941.31UniProt (Q9BYF1)
Pfam (PF01401)		Homo sapiens (human)
3C, D, E, F, G...
(A, B)		2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.26Chemie (NAG)
4I
(B)		ZINC IONnon-polymer65.41Chemie (ZN)
5J
(B)		waterwater18.01Chemie (HOH)
Sequence modifications
A: 1 - 1208 (UniProt: P0DTC2)
PDBExternal DatabaseDetails
Ile 19Thr 19variant
Ser 27Ala 27variant
Asp 142Gly 142variant
Gly 213Val 213variant
Asp 339Gly 339variant
Phe 371Ser 371variant
Pro 373Ser 373variant
Phe 375Ser 375variant
Ala 376Thr 376variant
Asn 405Asp 405variant
Ser 408Arg 408variant
Asn 417Lys 417variant
Lys 440Asn 440variant
Arg 452Leu 452variant
Asn 477Ser 477variant
Lys 478Thr 478variant
Ala 484Glu 484variant
Val 486Phe 486variant
Arg 498Gln 498variant
Tyr 501Asn 501variant
His 505Tyr 505variant
Gly 614Asp 614variant
Tyr 655His 655variant
Lys 679Asn 679variant
His 681Pro 681variant
Gly 682Arg 682variant
Ser 683Arg 683variant
Ser 685Arg 685variant
Lys 764Asn 764variant
Tyr 796Asp 796variant
His 954Gln 954variant
Lys 969Asn 969variant
Pro 986Lys 986variant
Pro 987Val 987variant
Gly 1209-linker
Ser 1210-linker
A: 1211 - 1237 (UniProt: P10104)
PDBExternal DatabaseDetails
Leu 1232Phe 479engineered mutation
Gly 1238-expression tag
Arg 1239-expression tag
Ser 1240-expression tag
Leu 1241-expression tag
Glu 1242-expression tag
Val 1243-expression tag
Leu 1244-expression tag
Phe 1245-expression tag
Gln 1246-expression tag
Gly 1247-expression tag
Pro 1248-expression tag
Gly 1249-expression tag
His 1250-expression tag
His 1251-expression tag
His 1252-expression tag
His 1253-expression tag
His 1254-expression tag
His 1255-expression tag
His 1256-expression tag
His 1257-expression tag
Ser 1258-expression tag
Ala 1259-expression tag
Trp 1260-expression tag
Ser 1261-expression tag
His 1262-expression tag
Pro 1263-expression tag
Gln 1264-expression tag
Phe 1265-expression tag
Glu 1266-expression tag
Lys 1267-expression tag
Gly 1268-expression tag
Gly 1269-expression tag
Gly 1270-expression tag
Ser 1271-expression tag
Gly 1272-expression tag
Gly 1273-expression tag
Gly 1274-expression tag
Gly 1275-expression tag
Ser 1276-expression tag
Gly 1277-expression tag
Gly 1278-expression tag
Ser 1279-expression tag
Ala 1280-expression tag
Trp 1281-expression tag
Ser 1282-expression tag
His 1283-expression tag
Pro 1284-expression tag
Gln 1285-expression tag
Phe 1286-expression tag
Glu 1287-expression tag
Lys 1288-expression tag
B: 19 - 620 (UniProt: Q9BYF1)
PDBExternal DatabaseDetails
Met -15-initiating methionine
Gly -14-expression tag
Thr -13-expression tag
Leu -12-expression tag
Ser -11-expression tag
Ala -10-expression tag
Pro -9-expression tag
Pro -8-expression tag
Cys -7-expression tag
Thr -6-expression tag
Gln -5-expression tag
Arg -4-expression tag
Ile -3-expression tag
Lys -2-expression tag
Trp -1-expression tag
Lys 0-expression tag
Gly 1-expression tag
Leu 2-expression tag
Leu 3-expression tag
Leu 4-expression tag
Thr 5-expression tag
Ala 6-expression tag
Ser 7-expression tag
Leu 8-expression tag
Leu 9-expression tag
Asn 10-expression tag
Phe 11-expression tag
Trp 12-expression tag
Asn 13-expression tag
Leu 14-expression tag
Pro 15-expression tag
Thr 16-expression tag
Thr 17-expression tag
Ala 18-expression tag
Gly 616Gln 616conflict
Leu 618Ile 618conflict
Glu 619Lys 619conflict
Leu 621-expression tag
Phe 622-expression tag
Gln 623-expression tag
Gly 624-expression tag
Pro 625-expression tag
Met 626-expression tag
Asp 627-expression tag
Glu 628-expression tag
Pro 629-expression tag
Arg 630-expression tag
Gly 631-expression tag
Pro 632-expression tag
Thr 633-expression tag
Ile 634-expression tag
Lys 635-expression tag
Pro 636-expression tag
Cys 637-expression tag
Pro 638-expression tag
Pro 639-expression tag
Cys 640-expression tag
Lys 641-expression tag
Cys 642-expression tag
Pro 643-expression tag
Ala 644-expression tag
Pro 645-expression tag
Asn 646-expression tag
Leu 647-expression tag
Leu 648-expression tag
Gly 649-expression tag
Gly 650-expression tag
Pro 651-expression tag
Ser 652-expression tag
Val 653-expression tag
Phe 654-expression tag
Ile 655-expression tag
Phe 656-expression tag
Pro 657-expression tag
Pro 658-expression tag
Lys 659-expression tag
Ile 660-expression tag
Lys 661-expression tag
Asp 662-expression tag
Val 663-expression tag
Leu 664-expression tag
Met 665-expression tag
Ile 666-expression tag
Ser 667-expression tag
Leu 668-expression tag
Ser 669-expression tag
Pro 670-expression tag
Ile 671-expression tag
Val 672-expression tag
Thr 673-expression tag
Cys 674-expression tag
Val 675-expression tag
Val 676-expression tag
Val 677-expression tag
Asp 678-expression tag
Val 679-expression tag
Ser 680-expression tag
Glu 681-expression tag
Asp 682-expression tag
Asp 683-expression tag
Pro 684-expression tag
Asp 685-expression tag
Val 686-expression tag
Gln 687-expression tag
Ile 688-expression tag
Ser 689-expression tag
Trp 690-expression tag
Phe 691-expression tag
Val 692-expression tag
Asn 693-expression tag
Asn 694-expression tag
Val 695-expression tag
Glu 696-expression tag
Val 697-expression tag
His 698-expression tag
Thr 699-expression tag
Ala 700-expression tag
Gln 701-expression tag
Thr 702-expression tag
Gln 703-expression tag
Thr 704-expression tag
His 705-expression tag
Arg 706-expression tag
Glu 707-expression tag
Asp 708-expression tag
Tyr 709-expression tag
Asn 710-expression tag
Ser 711-expression tag
Thr 712-expression tag
Leu 713-expression tag
Arg 714-expression tag
Val 715-expression tag
Val 716-expression tag
Ser 717-expression tag
Ala 718-expression tag
Leu 719-expression tag
Pro 720-expression tag
Ile 721-expression tag
Gln 722-expression tag
His 723-expression tag
Gln 724-expression tag
Asp 725-expression tag
Trp 726-expression tag
Met 727-expression tag
Ser 728-expression tag
Gly 729-expression tag
Lys 730-expression tag
Glu 731-expression tag
Phe 732-expression tag
Lys 733-expression tag
Cys 734-expression tag
Lys 735-expression tag
Val 736-expression tag
Asn 737-expression tag
Asn 738-expression tag
Lys 739-expression tag
Asp 740-expression tag
Leu 741-expression tag
Pro 742-expression tag
Ala 743-expression tag
Pro 744-expression tag
Ile 745-expression tag
Glu 746-expression tag
Arg 747-expression tag
Thr 748-expression tag
Ile 749-expression tag
Ser 750-expression tag
Lys 751-expression tag
Pro 752-expression tag
Lys 753-expression tag
Gly 754-expression tag
Ser 755-expression tag
Val 756-expression tag
Arg 757-expression tag
Ala 758-expression tag
Pro 759-expression tag
Gln 760-expression tag
Val 761-expression tag
Tyr 762-expression tag
Val 763-expression tag
Leu 764-expression tag
Pro 765-expression tag
Pro 766-expression tag
Pro 767-expression tag
Glu 768-expression tag
Glu 769-expression tag
Glu 770-expression tag
Met 771-expression tag
Thr 772-expression tag
Lys 773-expression tag
Lys 774-expression tag
Gln 775-expression tag
Val 776-expression tag
Thr 777-expression tag
Leu 778-expression tag
Thr 779-expression tag
Cys 780-expression tag
Met 781-expression tag
Val 782-expression tag
Thr 783-expression tag
Asp 784-expression tag
Phe 785-expression tag
Met 786-expression tag
Pro 787-expression tag
Glu 788-expression tag
Asp 789-expression tag
Ile 790-expression tag
Tyr 791-expression tag
Val 792-expression tag
Glu 793-expression tag
Trp 794-expression tag
Thr 795-expression tag
Asn 796-expression tag
Asn 797-expression tag
Gly 798-expression tag
Lys 799-expression tag
Thr 800-expression tag
Glu 801-expression tag
Leu 802-expression tag
Asn 803-expression tag
Tyr 804-expression tag
Lys 805-expression tag
Asn 806-expression tag
Thr 807-expression tag
Glu 808-expression tag
Pro 809-expression tag
Val 810-expression tag
Leu 811-expression tag
Asp 812-expression tag
Ser 813-expression tag
Asp 814-expression tag
Gly 815-expression tag
Ser 816-expression tag
Tyr 817-expression tag
Phe 818-expression tag
Met 819-expression tag
Tyr 820-expression tag
Ser 821-expression tag
Lys 822-expression tag
Leu 823-expression tag
Arg 824-expression tag
Val 825-expression tag
Glu 826-expression tag
Lys 827-expression tag
Lys 828-expression tag
Asn 829-expression tag
Trp 830-expression tag
Val 831-expression tag
Glu 832-expression tag
Arg 833-expression tag
Asn 834-expression tag
Ser 835-expression tag
Tyr 836-expression tag
Ser 837-expression tag
Cys 838-expression tag
Ser 839-expression tag
Val 840-expression tag
Val 841-expression tag
His 842-expression tag
Glu 843-expression tag
Gly 844-expression tag
Leu 845-expression tag
His 846-expression tag
Asn 847-expression tag
His 848-expression tag
His 849-expression tag
Thr 850-expression tag
Thr 851-expression tag
Lys 852-expression tag
Ser 853-expression tag
Phe 854-expression tag
Ser 855-expression tag
Arg 856-expression tag
Thr 857-expression tag
Pro 858-expression tag
Gly 859-expression tag
Lys 860-expression tag
His 861-expression tag
His 862-expression tag
His 863-expression tag
His 864-expression tag
His 865-expression tag
His 866-expression tag
His 867-expression tag
His 868-expression tag
His 869-expression tag
His 870-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight244629.4
Non-Polymers*Number of molecules7
Total formula weight1392.7
All*Total formula weight246022.0
*Water molecules are not included.

246704

PDB entries from 2025-12-24

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