8AQN
Crystal structure of PPARG and NCOR2 with BAY-4931, an inverse agonist (compound 6c)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Peroxisome proliferator-activated receptor gamma | polymer | 279 | 31863.0 | 2 | UniProt (P37231) Pfam (PF00104) | Homo sapiens (human) | PPAR-gamma,Nuclear receptor subfamily 1 group C member 3 |
| 2 | C, D (C, D) | Nuclear receptor corepressor 2 | polymer | 23 | 2638.1 | 2 | UniProt (Q9Y618) | Homo sapiens | N-CoR2,CTG repeat protein 26,SMAP270,Silencing mediator of retinoic acid and thyroid hormone receptor,SMRT,T3 receptor-associating factor,TRAC,Thyroid-,retinoic-acid-receptor-associated corepressor |
| 3 | E, G (A, B) | 2-chloranyl-~{N}-[2-(4-ethylphenyl)-1,3-benzoxazol-5-yl]-5-nitro-benzamide | non-polymer | 421.8 | 2 | Chemie (O0U) | |||
| 4 | F, H (A, C) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | I (C) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 6 | J, K, L, M (A, B, C, D) | water | water | 18.0 | 378 | Chemie (HOH) |
Sequence modifications
A, B: 203 - 477 (UniProt: P37231)
| PDB | External Database | Details |
|---|---|---|
| Gly 199 | - | expression tag |
| Ser 200 | - | expression tag |
| His 201 | - | expression tag |
| Met 202 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 69002.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1067.9 | |
| All* | Total formula weight | 70070.1 |
