8AK7

Human Sirt6 in complex with ADP-ribose and fragment 6-O-methylguanine

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	NAD-dependent protein deacetylase sirtuin-6	polymer	302	33631.6	2	UniProt (Q8N6T7) Pfam (PF02146) In PDB	Homo sapiens (human)	Regulatory protein SIR2 homolog 6,SIR2-like protein 6
2	A, B	[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE	non-polymer		559.3	2	Chemie (AR6)
3	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	A, B	6-O-methylguanine	non-polymer		165.2	2	Chemie (6GO)
5	A	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
6	A	TETRAETHYLENE GLYCOL	non-polymer		194.2	1	Chemie (PG4)
7	A, B	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	2	Chemie (PEG)
8	A, B	SULFATE ION	non-polymer		96.1	9	Chemie (SO4)
9	A, B	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
10	B	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
11		water	water		18.0	189	Chemie (HOH)

Sequence modifications

A, B: 13 - 308 (UniProt: Q8N6T7)

PDB	External Database	Details
Gly 7	-	expression tag
Ile 8	-	expression tag
Asp 9	-	expression tag
Pro 10	-	expression tag
Phe 11	-	expression tag
Thr 12	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	67263.2
Non-Polymers*	Number of molecules	24
	Total formula weight	3204.8
All*	Total formula weight	70468.0

*Water molecules are not included.