8A62
Small molecule stabilizer (compound 2) for FOXO1 and 14-3-3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | 14-3-3 protein sigma | polymer | 236 | 26542.9 | 1 | UniProt (P31947) Pfam (PF00244) In PDB | Homo sapiens (human) | Epithelial cell marker protein 1,Stratifin |
| 2 | B | Forkhead box protein O1 | polymer | 11 | 1388.4 | 1 | UniProt (Q12778) In PDB | Homo sapiens | Forkhead box protein O1A,Forkhead in rhabdomyosarcoma |
| 3 | A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | A | (3~{S})-1-[3,5-bis(chloranyl)-4-oxidanyl-phenyl]carbonyl-~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]piperidine-3-carboxamide | non-polymer | 480.5 | 1 | Chemie (L7L) | |||
| 5 | water | water | 18.0 | 364 | Chemie (HOH) |
Sequence modifications
A: 1 - 231 (UniProt: P31947)
B: 20 - 29 (UniProt: Q12778)
| PDB | External Database | Details |
|---|---|---|
| Gly -670 | - | expression tag |
| Ala -669 | - | expression tag |
| Met -668 | - | expression tag |
| Gly -667 | - | expression tag |
| Ser -666 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Nh2 30 | - | amidation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27931.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 529.1 | |
| All* | Total formula weight | 28460.4 |
