8A47

IdeS in complex with IgG1 Fc

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	IgG1 Fc	polymer	227	25555.0	2		Homo sapiens
2	C	IgG-degrading protease	polymer	308	34930.1	1	UniProt (A0A8B6IYA1) Pfam (PF09028) In PDB	Streptococcus pyogenes serotype M59
3	D	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1260.2	1	In PDB GlyTouCan (G45889JQ)
4	E	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1463.3	1	In PDB GlyTouCan (G80858MF)
5	C	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
6		water	water		18.0	200	Chemie (HOH)

Sequence modifications

C: 41 - 349 (UniProt: A0A8B6IYA1)

PDB	External Database	Details
Met 40	-	initiating methionine
Ala 94	Cys 94	engineered mutation
Leu 350	-	expression tag
Glu 351	-	expression tag
His 352	-	expression tag
His 353	-	expression tag
His 354	-	expression tag
His 355	-	expression tag
His 356	-	expression tag
His 357	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	86040.1
Branched	Number of molecules	2
	Total formula weight	2723.5
Non-Polymers*	Number of molecules	1
	Total formula weight	23.0
All*	Total formula weight	88786.6

*Water molecules are not included.