8A2J
human STING in complex with 2'-3'-cyclic-GMP-7-deaza(4-biphenylyl)-AMP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Stimulator of interferon genes protein | polymer | 241 | 27097.5 | 2 | UniProt (Q86WV6) Pfam (PF15009) | Homo sapiens (human) | hSTING,Endoplasmic reticulum interferon stimulator,ERIS,Mediator of IRF3 activation,hMITA,Transmembrane protein 173 |
| 2 | C (B) | 2-azanyl-9-[(1~{R},6~{R},8~{R},9~{R},10~{S},15~{R},17~{R},18~{R})-8-[4-azanyl-5-(4-phenylphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,9,12,18-tetrakis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-1~{H}-purin-6-one | non-polymer | 825.6 | 1 | Chemie (KWO) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 92 | Chemie (HOH) |
Sequence modifications
A, B: 140 - 379 (UniProt: Q86WV6)
| PDB | External Database | Details |
|---|---|---|
| Ser 139 | - | expression tag |
| Arg 232 | His 232 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54195.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 825.6 | |
| All* | Total formula weight | 55020.6 |
