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8A2I

human STING in complex with 2'-3'-cyclic-GMP-7-deaza(4-(2-naphthyl)phenyl)-AMP

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Stimulator of interferon genes proteinpolymer24127097.52UniProt (Q86WV6)
Pfam (PF15009)
Homo sapiens (human)hSTING,Endoplasmic reticulum interferon stimulator,ERIS,Mediator of IRF3 activation,hMITA,Transmembrane protein 173
2C
(A)
2-azanyl-9-[(1~{R},6~{R},8~{R},9~{R},10~{S},15~{R},17~{R},18~{R})-8-[4-azanyl-5-(4-naphthalen-2-ylphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,9,12,18-tetrakis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-3~{H}-purin-6-onenon-polymer875.71Chemie (KWF)
3D, E
(A, B)
waterwater18.0115Chemie (HOH)
Sequence modifications
A, B: 140 - 379 (UniProt: Q86WV6)
PDBExternal DatabaseDetails
Ser 139-expression tag
Arg 232His 232variant
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight54195.0
Non-Polymers*Number of molecules1
Total formula weight875.7
All*Total formula weight55070.7
*Water molecules are not included.

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PDB entries from 2025-07-23

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