Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

8A27

EGFR kinase domain in complex with 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[6-[2-[4-[[4-(hydroxymethyl)-1-piperidyl]methyl]phenyl]ethynyl]-1-oxo-4-(trifluoromethyl)isoindolin-2-yl]-N-thiazol-2-yl-acetamide

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Epidermal growth factor receptorpolymer32637225.11UniProt (P00533)
Pfam (PF07714)
Homo sapiens (human)Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1
2B, E, G
(A)
1,2-ETHANEDIOLnon-polymer62.13Chemie (EDO)
3C
(A)
(2R)-2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[5-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-3-oxidanylidene-7-(trifluoromethyl)-1H-isoindol-2-yl]-N-(1,3-thiazol-2-yl)ethanamidenon-polymer674.71Chemie (KY9)
4D, F
(A)
NITRATE IONnon-polymer62.02Chemie (NO3)
5H
(A)
waterwater18.0371Chemie (HOH)
Sequence modifications
A: 700 - 1022 (UniProt: P00533)
PDBExternal DatabaseDetails
Gly 697-expression tag
Ser 698-expression tag
Met 699-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight37225.1
Non-Polymers*Number of molecules6
Total formula weight984.9
All*Total formula weight38210.0
*Water molecules are not included.

237423

PDB entries from 2025-06-11

PDB statisticsPDBj update infoContact PDBjnumon