8A27
EGFR kinase domain in complex with 2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[6-[2-[4-[[4-(hydroxymethyl)-1-piperidyl]methyl]phenyl]ethynyl]-1-oxo-4-(trifluoromethyl)isoindolin-2-yl]-N-thiazol-2-yl-acetamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Epidermal growth factor receptor | polymer | 326 | 37225.1 | 1 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | B, E, G (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 3 | C (A) | (2R)-2-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-1-yl)-2-[5-[2-[4-[[4-(hydroxymethyl)piperidin-1-yl]methyl]phenyl]ethynyl]-3-oxidanylidene-7-(trifluoromethyl)-1H-isoindol-2-yl]-N-(1,3-thiazol-2-yl)ethanamide | non-polymer | 674.7 | 1 | Chemie (KY9) | |||
| 4 | D, F (A) | NITRATE ION | non-polymer | 62.0 | 2 | Chemie (NO3) | |||
| 5 | H (A) | water | water | 18.0 | 371 | Chemie (HOH) |
Sequence modifications
A: 700 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Gly 697 | - | expression tag |
| Ser 698 | - | expression tag |
| Met 699 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37225.1 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 984.9 | |
| All* | Total formula weight | 38210.0 |
