8A1R
cryo-EM structure of thioredoxin glutathione reductase in complex with a non-competitive inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Thioredoxin glutathione reductase | polymer | 598 | 65061.1 | 2 | UniProt (Q962Y6) Pfam (PF00462) Pfam (PF07992) Pfam (PF02852) In PDB | Schistosoma mansoni | |
| 2 | A, B | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 2 | Chemie (FAD) | |||
| 3 | A, B | (2~{R},3~{R},4~{S},5~{R})-2-[3-[[[(1~{R},2~{R},3~{R},5~{S})-2,6,6-trimethyl-3-bicyclo[3.1.1]heptanyl]amino]methyl]indol-1-yl]oxane-3,4,5-triol | non-polymer | 414.5 | 2 | Chemie (KW2) |
Sequence modifications
A, B: 1 - 598 (UniProt: Q962Y6)
| PDB | External Database | Details |
|---|---|---|
| Cys 597 | Unk 597 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 130122.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 2400.2 | |
| All* | Total formula weight | 132522.5 |
