8A0B
Inhibitor binding to HDAC2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Histone deacetylase 2 | polymer | 498 | 56560.3 | 3 | UniProt (Q92769) Pfam (PF00850) | Homo sapiens (human) | HD2,Protein deacylase HDAC2 |
| 2 | D, I, R (A, B, C) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 3 | E, J, S (A, B, C) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 4 | F, K, T (A, B, C) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 5 | G, M, O, P, U (A, B, C) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 5 | Chemie (PEG) | |||
| 6 | H, Q, W (A, B, C) | 1,3-dihydroisoindol-2-yl-[(2R,4S)-4-phenylpyrrolidin-1-ium-2-yl]methanone | non-polymer | 293.4 | 3 | Chemie (KRU) | |||
| 7 | L (B) | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID | non-polymer | 207.3 | 1 | Chemie (NHE) | |||
| 8 | N (B) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 9 | V (C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 10 | X, Y, Z (A, B, C) | water | water | 18.0 | 813 | Chemie (HOH) |
Sequence modifications
A, B, C: 5 - 492 (UniProt: Q92769)
| PDB | External Database | Details |
|---|---|---|
| Gly 493 | - | expression tag |
| Ser 494 | - | expression tag |
| Ser 495 | - | expression tag |
| Gly 496 | - | expression tag |
| His 497 | - | expression tag |
| His 498 | - | expression tag |
| His 499 | - | expression tag |
| His 500 | - | expression tag |
| His 501 | - | expression tag |
| His 502 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 169680.9 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 2259.8 | |
| All* | Total formula weight | 171940.6 |
