7ZZU
Inhibitory Ligand binding to HDAC2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C | Histone deacetylase 2 | polymer | 498 | 56560.3 | 3 | UniProt (Q92769) Pfam (PF00850) In PDB | Homo sapiens (human) | HD2,Protein deacylase HDAC2 |
| 2 | C, A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 3 | A, B | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 2 | Chemie (PG4) | |||
| 4 | C, A, B | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 6 | Chemie (PEG) | |||
| 5 | C, A, B | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 6 | C, A, B | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 7 | C, A, B | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 8 | B, C, A | 2-[4-[(2~{R},4~{S})-4-phenylpyrrolidin-2-yl]carbonylpiperazin-1-yl]pyridine-3-carbonitrile | non-polymer | 361.4 | 3 | Chemie (KKI) | |||
| 9 | A | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID | non-polymer | 207.3 | 1 | Chemie (NHE) | |||
| 10 | water | water | 18.0 | 413 | Chemie (HOH) |
Sequence modifications
A, B, C: 5 - 492 (UniProt: Q92769)
| PDB | External Database | Details |
|---|---|---|
| Gly 493 | - | expression tag |
| Ser 494 | - | expression tag |
| Ser 495 | - | expression tag |
| Gly 496 | - | expression tag |
| His 497 | - | expression tag |
| His 498 | - | expression tag |
| His 499 | - | expression tag |
| His 500 | - | expression tag |
| His 501 | - | expression tag |
| His 502 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 169680.9 | |
| Non-Polymers* | Number of molecules | 30 |
| Total formula weight | 3260.8 | |
| All* | Total formula weight | 172941.7 |
