7ZWT
Crystal structure of human BCL6 BTB domain in complex with compound 14
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | B-cell lymphoma 6 protein | polymer | 144 | 16499.0 | 1 | UniProt (P41182) Pfam (PF00651) | Homo sapiens (human) | BCL-6,B-cell lymphoma 5 protein,BCL-5,Protein LAZ-3,Zinc finger and BTB domain-containing protein 27,Zinc finger protein 51 |
| 2 | B (A) | 2-[(2-chlorophenyl)amino]-~{N}-(pyridin-2-ylmethyl)-1,3-thiazole-4-carboxamide | non-polymer | 344.8 | 1 | Chemie (K5U) | |||
| 3 | C (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | D, E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 5 | F (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 6 | G (A) | water | water | 18.0 | 98 | Chemie (HOH) |
Sequence modifications
A: 5 - 129 (UniProt: P41182)
| PDB | External Database | Details |
|---|---|---|
| Gly -14 | - | expression tag |
| Pro -13 | - | expression tag |
| Gly -12 | - | expression tag |
| Leu -11 | - | expression tag |
| Asp -10 | - | expression tag |
| Tyr -9 | - | expression tag |
| Lys -8 | - | expression tag |
| Asp -7 | - | expression tag |
| Asp -6 | - | expression tag |
| Asp -5 | - | expression tag |
| Asp -4 | - | expression tag |
| Lys -3 | - | expression tag |
| Glu -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Tyr 1 | - | expression tag |
| Phe 2 | - | expression tag |
| Gln 3 | - | expression tag |
| Gly 4 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 16499.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 582.5 | |
| All* | Total formula weight | 17081.5 |
