7ZWE
The Crystal structure of GW8695 bound to CK2alpha
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Casein kinase II subunit alpha | polymer | 327 | 38944.3 | 1 | UniProt (P68400) Pfam (PF00069) | Homo sapiens (human) | CK II alpha |
| 2 | B (A) | 7-(1~{H}-indol-2-yl)-5-methyl-~{N}-(3,4,5-trimethoxyphenyl)imidazo[5,1-f][1,2,4]triazin-2-amine | non-polymer | 430.5 | 1 | Chemie (QXZ) | |||
| 3 | C (A) | water | water | 18.0 | 175 | Chemie (HOH) |
Sequence modifications
A: 3 - 329 (UniProt: P68400)
| PDB | External Database | Details |
|---|---|---|
| Ser 21 | Arg 21 | engineered mutation |
| Ala 74 | Lys 74 | engineered mutation |
| Ala 75 | Lys 75 | engineered mutation |
| Ala 76 | Lys 76 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38944.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 430.5 | |
| All* | Total formula weight | 39374.8 |
