7ZW8
Identification of M4205 a highly selective inhibitor of cKIT mutations for unresectable metastatic or recurrent GIST
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Mast/stem cell growth factor receptor Kit | polymer | 327 | 37178.0 | 1 | UniProt (P10721) Pfam (PF07714) In PDB | Homo sapiens (human) | SCFR,Piebald trait protein,PBT,Proto-oncogene c-Kit,Tyrosine-protein kinase Kit,p145 c-kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| 2 | A | ~{N}-[[4-(1-methylpyrazol-4-yl)phenyl]methyl]-6-[7-(3-pyrrolidin-1-ylpropoxy)imidazo[1,2-a]pyridin-3-yl]pyrimidin-4-amine | non-polymer | 508.6 | 1 | Chemie (K3R) | |||
| 3 | water | water | 18.0 | 40 | Chemie (HOH) |
Sequence modifications
A: 551 - 935 (UniProt: P10721)
| PDB | External Database | Details |
|---|---|---|
| Thr 752 | Gln 694 | conflict |
| - | Asp 696 | deletion |
| - | His 697 | deletion |
| - | Ala 698 | deletion |
| - | Glu 699 | deletion |
| - | Ala 700 | deletion |
| - | Ala 701 | deletion |
| - | Leu 702 | deletion |
| - | Tyr 703 | deletion |
| - | Lys 704 | deletion |
| - | Asn 705 | deletion |
| - | Leu 706 | deletion |
| - | Leu 707 | deletion |
| - | His 708 | deletion |
| - | Ser 709 | deletion |
| - | Lys 710 | deletion |
| - | Glu 711 | deletion |
| - | Ser 712 | deletion |
| - | Ser 713 | deletion |
| - | Cys 714 | deletion |
| - | Ser 715 | deletion |
| - | Asp 716 | deletion |
| - | Ser 717 | deletion |
| - | Thr 718 | deletion |
| - | Asn 719 | deletion |
| - | Glu 720 | deletion |
| - | Tyr 721 | deletion |
| - | Met 722 | deletion |
| - | Asp 723 | deletion |
| - | Met 724 | deletion |
| - | Lys 725 | deletion |
| - | Pro 726 | deletion |
| - | Gly 727 | deletion |
| - | Val 728 | deletion |
| - | Ser 729 | deletion |
| - | Tyr 730 | deletion |
| - | Val 731 | deletion |
| - | Val 732 | deletion |
| - | Pro 733 | deletion |
| - | Thr 734 | deletion |
| - | Lys 735 | deletion |
| - | Ala 736 | deletion |
| - | Asp 737 | deletion |
| - | Lys 738 | deletion |
| - | Arg 739 | deletion |
| - | Arg 740 | deletion |
| - | Ser 741 | deletion |
| - | Val 742 | deletion |
| - | Arg 743 | deletion |
| - | Ile 744 | deletion |
| - | Gly 745 | deletion |
| - | Ser 746 | deletion |
| - | Tyr 747 | deletion |
| - | Ile 748 | deletion |
| - | Glu 749 | deletion |
| - | Arg 750 | deletion |
| - | Asp 751 | deletion |
| - | Val 752 | deletion |
| - | Thr 753 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37178.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 508.6 | |
| All* | Total formula weight | 37686.6 |
