7ZVF
Crystal structure of human cathepsin L in complex with covalently bound CLIK148
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Cathepsin L | polymer | 220 | 24161.7 | 4 | UniProt (P07711) Pfam (PF00112) | Homo sapiens (human) | |
| 2 | E, M, R, W (A, B, C, D) | (2S)-N-[(2S)-1-(dimethylamino)-1-oxidanylidene-3-phenyl-propan-2-yl]-2-oxidanyl-N'-(2-pyridin-2-ylethyl)butanediamide | non-polymer | 412.5 | 4 | Chemie (KXL) | |||
| 3 | F (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 4 | BA, G, P, T (D, A, B, C) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 4 | Chemie (1PE) | |||
| 5 | CA, DA, EA, H, I... (D, A, B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 7 | Chemie (DMS) | |||
| 6 | AA, J, K, L, S... (D, A, C) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 8 | Chemie (PEG) | |||
| 7 | Q, V (B, C) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 8 | U (C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 9 | FA, GA, HA, IA (A, B, C, D) | water | water | 18.0 | 497 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 220 (UniProt: P07711)
| PDB | External Database | Details |
|---|---|---|
| Ala 110 | Thr 223 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 96646.7 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 4301.2 | |
| All* | Total formula weight | 100947.9 |
