7ZV3

Crystal structure of indoleamine 2,3-dioxygenase 1 (IDO1) in complex with ferric heme and MMG-0472

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Indoleamine 2,3-dioxygenase 1	polymer	423	47504.5	2	UniProt (P14902) Pfam (PF01231)	Homo sapiens (human)	IDO-1,Indoleamine-pyrrole 2,3-dioxygenase
2	C, G (A, B)	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	2	Chemie (HEM)
3	D, H (A, B)	4-(3-chloro-2-phenethylphenyl)-1H-1,2,3-triazole	non-polymer		283.8	2	Chemie (RCT)
4	E (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5	F, I (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
6	J, K (A, B)	water	water		18.0	52	Chemie (HOH)

Sequence modifications

A, B: 1 - 403 (UniProt: P14902)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
Ser 3	His 3	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	95009.0
Non-Polymers*	Number of molecules	7
	Total formula weight	2084.7
All*	Total formula weight	97093.7

*Water molecules are not included.