7ZUD
Crystal structure of HIV-1 capsid IP6-CPSF6 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Capsid protein p24 | polymer | 233 | 25703.5 | 1 | UniProt (P12497) Pfam (PF19317) | Human immunodeficiency virus 1 | CA |
| 2 | B (M) | Cleavage and polyadenylation specificity factor subunit 6 | polymer | 13 | 1380.6 | 1 | UniProt (Q16630) | Homo sapiens | Cleavage and polyadenylation specificity factor 68 kDa subunit,CPSF 68 kDa subunit,Cleavage factor Im complex 68 kDa subunit,CFIm68,Pre-mRNA cleavage factor Im 68 kDa subunit,Protein HPBRII-4/7 |
| 3 | C, D (A) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 2 | Chemie (IHP) | |||
| 4 | E (A) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A: 1 - 231 (UniProt: P12497)
| PDB | External Database | Details |
|---|---|---|
| Cys 14 | Ala 146 | engineered mutation |
| Cys 45 | Glu 177 | engineered mutation |
| Ala 184 | Trp 316 | engineered mutation |
| Ala 185 | Met 317 | engineered mutation |
| Leu 232 | - | expression tag |
| Glu 233 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27084.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1320.1 | |
| All* | Total formula weight | 28404.2 |
