7ZT0
Crystal structure of CYP125 from Mycobacterium tuberculosis in complex with an inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Steroid C26-monooxygenase | polymer | 418 | 46663.4 | 2 | UniProt (P9WPP1) Pfam (PF00067) In PDB | Mycobacterium tuberculosis H37Rv | Cholest-4-en-3-one 26-monooxygenase,Cholest-4-en-3-one C26-monooxygenase [(25S)-3-oxocholest-4-en-26-oate forming],Cholesterol C26-monooxygenase,Cholesterol C26-monooxygenase [(25S)-3beta-hydroxycholest-5-en-26-oate forming],Cytochrome P450 125,Steroid C27-monooxygenase |
| 2 | A, B | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 3 | A, B | 1-(2-piperazin-1-ylethyl)-5-pyridin-4-yl-indole-2-carboxamide | non-polymer | 349.4 | 2 | Chemie (JUR) | |||
| 4 | A, B | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 5 | A, B | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 6 | water | water | 18.0 | 299 | Chemie (HOH) |
Sequence modifications
A, B: 18 - 433 (UniProt: P9WPP1)
| PDB | External Database | Details |
|---|---|---|
| Asn 16 | - | expression tag |
| Gly 17 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 93326.8 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 2554.0 | |
| All* | Total formula weight | 95880.7 |
