7ZRT
Crystal structure of human Urokinase-type plasminogen activator in complex with bicycle peptide inhibitor UK970
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Urokinase-type plasminogen activator | polymer | 253 | 28442.4 | 1 | UniProt (P00749) Pfam (PF00089) | Homo sapiens (human) | uPA |
| 2 | B (B) | synthetic peptide uk970 | polymer | 17 | 1670.0 | 1 | synthetic construct | ||
| 3 | C, D (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E, K (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 5 | F, G, H (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 6 | I (A) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
| 7 | J (B) | 1,3,5-tris(bromomethyl)benzene | non-polymer | 356.9 | 1 | Chemie (ZBR) | |||
| 8 | L, M (A, B) | water | water | 18.0 | 119 | Chemie (HOH) |
Sequence modifications
A: 1 - 253 (UniProt: P00749)
| PDB | External Database | Details |
|---|---|---|
| Ala 121 | Cys 282 | engineered mutation |
| Gln 144 | Asn 305 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30112.3 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1185.7 | |
| All* | Total formula weight | 31298.1 |
