7ZRR
Crystal structure of human Urokinase-type plasminogen activator in complex with bicycle peptide inhibitor UK965
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Urokinase-type plasminogen activator | polymer | 284 | 31872.3 | 1 | UniProt (P00749) Pfam (PF00089) | Homo sapiens (human) | U-plasminogen activator,uPA |
| 2 | B (B) | synthetic peptide UK965 | polymer | 16 | 1717.9 | 1 | Homo sapiens (Human) | ||
| 3 | C (A) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
| 4 | D, E (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 5 | F (B) | AMINO GROUP | non-polymer | 16.0 | 1 | Chemie (NH2) | |||
| 6 | G (B) | 1,3,5-tris(bromomethyl)benzene | non-polymer | 356.9 | 1 | Chemie (ZBR) | |||
| 7 | H, I (A, B) | water | water | 18.0 | 125 | Chemie (HOH) |
Sequence modifications
A: -24 - 253 (UniProt: P00749)
| PDB | External Database | Details |
|---|---|---|
| Asp -30 | - | expression tag |
| Ala -29 | - | expression tag |
| Ala -28 | - | expression tag |
| Gln -27 | - | expression tag |
| Pro -26 | - | expression tag |
| Ala -25 | - | expression tag |
| Ala 121 | Cys 299 | engineered mutation |
| Gln 144 | Asn 322 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33590.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 735.3 | |
| All* | Total formula weight | 34325.6 |
