7ZR2

Crystal structure of a chimeric protein mimic of SARS-CoV-2 Spike HR1 in complex with HR2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Spike protein S2',Chimeric protein mimic of SARS-CoV-2 Spike HR1	polymer	241	26577.7	1	UniProt (P0DTC2) Pfam (PF01601)	Severe acute respiratory syndrome coronavirus 2
2	B (B)	Spike protein S2'	polymer	44	4673.1	1	UniProt (P0DTC2)	Severe acute respiratory syndrome coronavirus 2
3	C, D (A, B)	water	water		18.0	304	Chemie (HOH)

Sequence modifications

A: 1 - 73 (UniProt: P0DTC2)

PDB	External Database	Details
Met 0	-	initiating methionine
Asp 1	Asn 914	engineered mutation
Lys 13	Gln 926	engineered mutation
Glu 31	Ala 944	engineered mutation
Glu 38	Val 951	engineered mutation
Asp 45	Ala 958	engineered mutation
Arg 59	Ala 972	engineered mutation
Glu 63	Val 976	engineered mutation

A: 73 - 154 (PDB: 7ZR2)
A: 155 - 229 (UniProt: P0DTC2)

PDB	External Database	Details
Glu 165	Ala 924	engineered mutation
Lys 183	Ala 942	engineered mutation
Lys 190	Gln 949	engineered mutation
Lys 197	Ala 956	engineered mutation
Lys 222	Leu 981	engineered mutation
Gly 230	-	expression tag
Gly 231	-	expression tag
Gly 232	-	expression tag
Gly 233	-	expression tag
Ser 234	-	expression tag
His 235	-	expression tag
His 236	-	expression tag
His 237	-	expression tag
His 238	-	expression tag
His 239	-	expression tag
His 240	-	expression tag

B: 1163 - 1206 (UniProt: P0DTC2)

PDB	External Database	Details
Ace 1163	Asp 1163	conflict
Ser 1203	Leu 1203	conflict
Gly 1205	Lys 1205	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	31250.8
All*	Total formula weight	31250.8

*Water molecules are not included.