7ZMH
CryoEM structure of mitochondrial complex I from Chaetomium thermophilum (state 1) - membrane arm
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | 1 | NADH-ubiquinone oxidoreductase chain 1 | polymer | 378 | 41716.4 | 1 | UniProt (G1DJA6) Pfam (PF00146) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit ND1 of NADH-ubiquinone oxidoreductase (Complex I) |
2 | 2 | NADH dehydrogenase subunit 2 | polymer | 571 | 64129.2 | 1 | UniProt (G1DJ98) Pfam (PF00361) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit ND2 of NADH-ubiquinone oxidoreductase (Complex I) |
3 | 3 | NADH-ubiquinone oxidoreductase chain 3 | polymer | 146 | 16330.0 | 1 | UniProt (G1DJ99) Pfam (PF00507) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit ND3 of NADH-ubiquinone oxidoreductase (Complex I) |
4 | 4 | NADH-ubiquinone oxidoreductase chain 4 | polymer | 542 | 60810.3 | 1 | UniProt (G1DJA7) Pfam (PF00361) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit ND4 of NADH-ubiquinone oxidoreductase (Complex I) |
5 | 5 | NADH-ubiquinone oxidoreductase chain 5 | polymer | 679 | 75872.0 | 1 | UniProt (G1DJA3) Pfam (PF00662) Pfam (PF00361) Pfam (PF06455) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit ND5 of NADH-ubiquinone oxidoreductase (Complex I) |
6 | 6 | NADH-ubiquinone oxidoreductase chain 6 | polymer | 224 | 24819.3 | 1 | UniProt (G1DJ96) Pfam (PF00499) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit ND6 of NADH-ubiquinone oxidoreductase (Complex I) |
7 | 8 | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | polymer | 86 | 10312.8 | 1 | UniProt (G0SAE9) Pfam (PF05676) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit NDUFB7 of NADH-ubiquinone oxidoreductase (Complex I) |
8 | 9 | Subunit NDUFS5 of NADH-ubiquinone oxidoreductase (Complex I) | polymer | 785 | 87142.3 | 1 | UniProt (G0SG48) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit NDUFS5 of NADH-ubiquinone oxidoreductase (Complex I) |
9 | D | Subunit NDUFA1 of NADH-ubiquinone oxidoreductase (Complex I) | polymer | 86 | 9833.4 | 1 | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit NDUFA1 of NADH-ubiquinone oxidoreductase (Complex I) | |
10 | J | NADH-ubiquinone oxidoreductase-like protein | polymer | 199 | 21612.6 | 1 | UniProt (G0S2B3) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit NDUFA11 of NADH-ubiquinone oxidoreductase (Complex I) |
11 | L | NADH-ubiquinone oxidoreductase chain 4L | polymer | 89 | 9838.0 | 1 | UniProt (G1DJA2) Pfam (PF00420) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit ND4L of NADH-ubiquinone oxidoreductase (Complex I) |
12 | Q | Acyl carrier protein | polymer | 141 | 15593.6 | 1 | UniProt (G0SBG9) Pfam (PF00550) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit NDUFAB1 of NADH-ubiquinone oxidoreductase (Complex I) |
13 | R | Complex I-B22 | polymer | 99 | 11636.5 | 1 | UniProt (G0SAY0) Pfam (PF05347) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit NDUFB9 of NADH-ubiquinone oxidoreductase (Complex I) |
14 | S | Complex I-ESSS | polymer | 143 | 15847.8 | 1 | UniProt (G0SAN0) Pfam (PF10183) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit NDUFB11 of NADH-ubiquinone oxidoreductase (Complex I) |
15 | U | NADH-ubiquinone oxidoreductase | polymer | 186 | 21517.6 | 1 | UniProt (G0S0R3) Pfam (PF06747) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit NDUFA8 of NADH-ubiquinone oxidoreductase (Complex I) |
16 | W | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | polymer | 121 | 14039.2 | 1 | UniProt (G0SB83) Pfam (PF06212) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit NDUFA13 of NADH-ubiquinone oxidoreductase (Complex I) |
17 | X | NADH-ubiquinone oxidoreductase-like protein | polymer | 191 | 21645.5 | 1 | UniProt (G0S0S8) Pfam (PF10785) Pfam (PF12853) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit NUXM of NADH-ubiquinone oxidoreductase (Complex I) |
18 | a | NADH dehydrogenase (Ubiquinone)-like protein | polymer | 815 | 89210.1 | 1 | UniProt (G0RXU4) Pfam (PF05821) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit NDUFB8 of NADH-ubiquinone oxidoreductase (Complex I) |
19 | b | Subunit NDUFC2 of NADH-ubiquinone oxidoreductase (Complex I) | polymer | 94 | 10823.5 | 1 | UniProt (G0S812) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit NDUFC2 of NADH-ubiquinone oxidoreductase (Complex I) |
20 | c | Subunit NDUFB3 of NADH-ubiquinone oxidoreductase (Complex I) | polymer | 93 | 11153.5 | 1 | UniProt (G0S681) Pfam (PF08122) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit NDUFB3 of NADH-ubiquinone oxidoreductase (Complex I) |
21 | d | Subunit NDUFB10 of NADH-ubiquinone oxidoreductase (Complex I) | polymer | 105 | 12514.3 | 1 | UniProt (G0SEZ1) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit NDUFB10 of NADH-ubiquinone oxidoreductase (Complex I) |
22 | e | Subunit NDUFB2 of NADH-ubiquinone oxidoreductase (Complex I) | polymer | 46 | 5278.1 | 1 | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit NDUFB2 of NADH-ubiquinone oxidoreductase (Complex I) | |
23 | g | Subunit NDUFA3 of NADH-ubiquinone oxidoreductase (Complex I) | polymer | 82 | 9076.5 | 1 | UniProt (G0RZZ2) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit NDUFA3 of NADH-ubiquinone oxidoreductase (Complex I) |
24 | i | Subunit NDUFB6 of NADH-ubiquinone oxidoreductase (Complex I) | polymer | 93 | 10857.3 | 1 | UniProt (G0S569) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit NDUFB6 of NADH-ubiquinone oxidoreductase (Complex I) |
25 | j | Subunit NDUFB4 of NADH-ubiquinone oxidoreductase (Complex I) | polymer | 75 | 8760.3 | 1 | UniProt (G0S5C8) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit NDUFB4 of NADH-ubiquinone oxidoreductase (Complex I) |
26 | n | Subunit NDUFB5 of NADH-ubiquinone oxidoreductase (Complex I) | polymer | 184 | 20824.3 | 1 | UniProt (G0S086) In PDB | Chaetomium thermophilum var. thermophilum DSM 1495 | Subunit NDUFB5 of NADH-ubiquinone oxidoreductase (Complex I) |
27 | 1, g, i, 4, n... | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 17 | Chemie (3PE) | |||
28 | X, 1, 3, 4, 5... | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 8 | Chemie (PC1) | |||
29 | 2, D, S, X | CARDIOLIPIN | non-polymer | 1464.0 | 5 | Chemie (CDL) | |||
30 | 2, j, 4 | Lauryl Maltose Neopentyl Glycol | non-polymer | 1005.2 | 3 | Chemie (LMN) | |||
31 | Q | S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] tetradecanethioate | non-polymer | 568.7 | 1 | Chemie (ZMP) | |||
32 | water | water | 18.0 | 1111 | Chemie (HOH) |
Sequence modifications
5: 1 - 679 (UniProt: G1DJA3)
9: 1 - 785 (UniProt: G0SG48)
a: 1 - 815 (UniProt: G0RXU4)
n: 53 - 184 (UniProt: G0S086)
PDB | External Database | Details |
---|---|---|
Arg 445 | - | insertion |
Leu 446 | - | insertion |
Ala 447 | - | insertion |
Ile 448 | - | insertion |
Asp 449 | - | insertion |
Asn 450 | - | insertion |
Phe 451 | - | insertion |
Phe 452 | - | insertion |
Ser 453 | - | insertion |
Ala 454 | - | insertion |
Gln 455 | - | insertion |
Ala 456 | - | insertion |
Ile 457 | - | insertion |
Lys 458 | - | insertion |
PDB | External Database | Details |
---|---|---|
Val 100 | - | insertion |
PDB | External Database | Details |
---|---|---|
Val 166 | Ala 166 | conflict |
Ala 168 | Met 168 | conflict |
- | Glu 169 | deletion |
- | Gly 170 | deletion |
- | Asp 171 | deletion |
- | Pro 172 | deletion |
- | Asp 173 | deletion |
- | Pro 174 | deletion |
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
Leu 2 | - | insertion |
Ala 3 | - | insertion |
Leu 4 | - | insertion |
Arg 5 | - | insertion |
Gln 6 | - | insertion |
Arg 7 | - | insertion |
Ala 8 | - | insertion |
Ala 9 | - | insertion |
Leu 10 | - | insertion |
Leu 11 | - | insertion |
Ala 12 | - | insertion |
Arg 13 | - | insertion |
Arg 14 | - | insertion |
Val 15 | - | insertion |
Arg 16 | - | insertion |
Pro 17 | - | insertion |
Thr 18 | - | insertion |
Val 19 | - | insertion |
Val 20 | - | insertion |
Val 21 | - | insertion |
Pro 22 | - | insertion |
Arg 23 | - | insertion |
Asn 24 | - | insertion |
Ala 25 | - | insertion |
Arg 26 | - | insertion |
Thr 27 | - | insertion |
Tyr 28 | - | insertion |
Ala 29 | - | insertion |
Ser 30 | - | insertion |
Ser 31 | - | insertion |
His 32 | - | insertion |
Asp 33 | - | insertion |
His 34 | - | insertion |
Asp 35 | - | insertion |
His 36 | - | insertion |
His 37 | - | insertion |
Asp 38 | - | insertion |
His 39 | - | insertion |
His 40 | - | insertion |
His 41 | - | insertion |
Asp 42 | - | insertion |
His 43 | - | insertion |
Gly 44 | - | insertion |
His 45 | - | insertion |
Asn 46 | - | insertion |
Val 47 | - | insertion |
Glu 48 | - | insertion |
Glu 49 | - | insertion |
Pro 50 | - | insertion |
Leu 51 | - | insertion |
Gly 52 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 26 |
Total formula weight | 701194.6 | |
Non-Polymers* | Number of molecules | 34 |
Total formula weight | 29942.7 | |
All* | Total formula weight | 731137.3 |