7ZLS
co-crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 13
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D, G, J (A, D, J, G) | Suppressor of cytokine signaling 2 | polymer | 169 | 19273.3 | 4 | UniProt (O14508) Pfam (PF00017) Pfam (PF07525) | Homo sapiens (human) | SOCS-2,Cytokine-inducible SH2 protein 2,CIS-2,STAT-induced STAT inhibitor 2,SSI-2 |
| 2 | B, E, H, K (B, E, K, H) | Elongin-B | polymer | 118 | 13147.8 | 4 | UniProt (Q15370) Pfam (PF00240) | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
| 3 | C, F, I, L (C, F, L, I) | Elongin-C | polymer | 97 | 10974.6 | 4 | UniProt (Q15369) Pfam (PF03931) | Homo sapiens (human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
| 4 | M (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | N, O, P, Q (A, D, J, G) | [4-[(2~{S})-3-[(4-fluoranyl-3-prop-2-enyl-phenyl)methylamino]-2-[2-(4-fluorophenyl)ethanoylamino]-3-oxidanylidene-propyl]phenyl] dihydrogen phosphate | non-polymer | 544.5 | 4 | Chemie (JH9) | |||
| 6 | AA, BA, CA, R, S... (G, H, I, A, B...) | water | water | 18.0 | 543 | Chemie (HOH) |
Sequence modifications
A, D, J, G: 32 - 198 (UniProt: O14508)
C, F, L, I: 17 - 112 (UniProt: Q15369)
| PDB | External Database | Details |
|---|---|---|
| Ser 30 | - | expression tag |
| Met 31 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 16 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 173582.7 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 2240.0 | |
| All* | Total formula weight | 175822.7 |
