7ZLN
Crystal structure of SOCS2:ElonginB:ElonginC in complex with compound 11
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Suppressor of cytokine signaling 2 | polymer | 169 | 19273.3 | 1 | UniProt (O14508) Pfam (PF00017) Pfam (PF07525) In PDB | Homo sapiens (human) | SOCS-2,Cytokine-inducible SH2 protein 2,CIS-2,STAT-induced STAT inhibitor 2,SSI-2 |
2 | B | Elongin-B | polymer | 118 | 13147.8 | 1 | UniProt (Q15370) Pfam (PF00240) In PDB | Homo sapiens (human) | EloB,Elongin 18 kDa subunit,RNA polymerase II transcription factor SIII subunit B,SIII p18,Transcription elongation factor B polypeptide 2 |
3 | C | Elongin-C | polymer | 97 | 10974.6 | 1 | UniProt (Q15369) Pfam (PF03931) In PDB | Homo sapiens (human) | EloC,Elongin 15 kDa subunit,RNA polymerase II transcription factor SIII subunit C,SIII p15,Transcription elongation factor B polypeptide 1 |
4 | A | [4-[(2~{S})-3-[(4-fluoranyl-3-methyl-phenyl)methylamino]-2-[2-(4-fluorophenyl)ethanoylamino]-3-oxidanylidene-propyl]phenyl] dihydrogen phosphate | non-polymer | 518.4 | 1 | Chemie (JI9) | |||
5 | water | water | 18.0 | 28 | Chemie (HOH) |
Sequence modifications
A: 32 - 198 (UniProt: O14508)
C: 17 - 112 (UniProt: Q15369)
PDB | External Database | Details |
---|---|---|
Ser 30 | - | expression tag |
Met 31 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 16 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 43395.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 518.4 | |
All* | Total formula weight | 43914.1 |