7ZKN

X-ray structure of the complex between human alpha thrombin and a pseudo-cyclic thrombin binding aptamer (TBA-NNp/DDp) - Crystal form gamma

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Thrombin light chain	polymer	36	4096.5	2	UniProt (P00734) Pfam (PF09396)	Homo sapiens (human)
2	B, D (B, D)	Thrombin heavy chain	polymer	259	29780.2	2	UniProt (P00734) Pfam (PF00089)	Homo sapiens (human)
3	E, F, G, H (E, F, G, I)	TBA-NNp/DDp	polymer	15	4743.1	4		synthetic construct
4	I, J (H, J)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
5	K, L (B, D)	D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide	non-polymer		454.0	2	Chemie (0G6)
6	M, P, S, V (E, F, G, I)	3-[13-methyl-5,7,12,14-tetrakis(oxidanylidene)-6,13-diazatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1(15),2,4(16),8,10-pentaen-6-yl]propyl 3-[5,7,12,14-tetrakis(oxidanylidene)-13-(3-oxidanylpropyl)-6,13-diazatetracyclo[6.6.2.0^{4,16}.0^{11,15}]hexadeca-1,3,8(16),9,11(15)-pentaen-6-yl]propyl hydrogen phosphate	non-polymer		1044.7	4	Chemie (JL0)
7	N, Q, T, W (E, F, G, I)	3-[5-[3-bis(oxidanyl)phosphanyloxypropoxy]naphthalen-1-yl]oxypropyl 3-(5-oxidanylnaphthalen-1-yl)oxypropyl hydrogen phosphate	non-polymer		620.5	4	Chemie (JKR)
8	O, R, U, X (E, F, G, I)	POTASSIUM ION	non-polymer		39.1	4	Chemie (K)
9	AA, BA, CA, DA, Y... (C, D, E, G, A...)	water	water		18.0	29	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	86725.7
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	14
	Total formula weight	7725.4
All*	Total formula weight	95299.9

*Water molecules are not included.